Kyoto University · 신경과학
카즈키 나가야수 교수의 연구실은 도파민성 보상 및 회피 반응 조절에 관여하는 덮개핵(5-HT) 신경세포의 기능, 특히 전두엽 피질과 해마의 긍정적 기억 관련 신경회로와의 상호작용을 중심으로 연구를 진행하고 있습니다. 특히 항우울제의 작용 메커니즘, 특히 선택적 세로토닌 재흡수 억제제(SSRI)가 세로토닌 방출 메커니즘에 미치는 장기적 신경적 적응 변화를 분자 및 세포 수준에서 규명하고 있습니다. 카이네트산, 아세틸콜린 수용체, AMPA/카이네이트 수용체 등 신경전달물질 수용체와의 상호작용을 통해 항우울 효과의 분자 기반을 밝히는 데 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Our findings indicate that the activity of DRN 5-HT neurons projecting to the VTA is a key modulator of balance between reward and aversion.
These results suggest the ketamine-induced serotonin release in medial prefrontal cortex is mediated by cholinergic neurons projecting from pedunculopontine tegmental nucleus to dorsal raphe nucleus via α4β2 nAChRs.
Major depressive disorder (MDD) is among the most common mental illnesses. Serotonergic (5-HT) neurons are central to the pathophysiology and treatment of MDD. Repeatedly recalling positive episodes is effective for MDD. Stimulating 5-HT neurons of the dorsal raphe nucleus (DRN) or neuronal ensembles in the dorsal dentate gyrus (dDG) associated with positive memories reverses the stress-induced behavioral abnormalities. Despite this phenotypic similarity, their causal relationship is unclear. Th
These results suggest that sustained exposure to SSRIs induces the augmentation of exocytotic 5-HT release, which is caused, at least in part, by the activation of AMPA/kainate receptors in the raphe slice cultures.
Most clinically-used antidepressants acutely increase monoamine levels in synaptic clefts, while their therapeutic effects often require several weeks of administration. Slow neuroadaptive changes in serotonergic neurons are considered to underlie this delayed onset of beneficial actions. Recently, we reported that sustained exposure of rat organotypic raphe slice cultures containing abundant serotonergic neurons to selective serotonin (5-HT) reuptake inhibitors (citalopram, fluoxetine and parox
