The University of Osaka · 의학
카즈코 카네다-나카시마 교수의 연구실은 주로 암 치료를 목표로 한 표적형 알파 방사성 동위원소 치료(TAT) 기반의 신약 개발을 핵심으로 합니다. 특히 LAT1과 FAP 등 암 세포나 종양 미세환경을 특이적으로 표적으로 삼는 프로브를 설계하고, <sup>211</sup>At와 같은 알파 붕괴 방사성 동위원소를 결합하여 암세포에 정밀하게 약물과 방사선을 전달하는 전략을 연구하고 있습니다. 또한 알레르기 반응 메커니즘과 같은 면역학적 질환의 분자 기전에 대해서도 기초 연구를 수행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
α-Methyl-l-tyrosine (AMT) has a high affinity for the cancer-specific l-type amino acid transporter 1 (LAT1). Therefore, we established an anti-cancer therapy, with <sup>211</sup> At-labeled α-methyl-l-tyrosine (<sup>211</sup> At-AAMT) as a carrier of <sup>211</sup> At into tumors. <sup>211</sup> At-AAMT had high affinity for LAT1, inhibited tumor cell growth, and induced DNA double-stranded breaks in vitro. We evaluated the accumulation of <sup>211</sup> At-AAMT in vivo and the role of LAT1. Tr
Fibroblast activation proteins (FAP) are overexpressed in the tumor stroma and have received attention as target molecules for radionuclide therapy. The FAP inhibitor (FAPI) is used as a probe to deliver nuclides to cancer tissues. In this study, we designed and synthesized four novel <sup>211</sup>At-FAPI(s) possessing polyethylene glycol (PEG) linkers between the FAP-targeting and <sup>211</sup>At-attaching moieties. <sup>211</sup>At-FAPI(s) and piperazine (PIP) linker FAPI exhibited distinct
Isocyanates are very useful chemicals, and these are important for our daily life. Various products, especially urethane resin, are made from these chemicals. There is no substitute for isocyanates at the present. Isocyanates are patent agents to provoke immunological responses. This article deals with the case reports of hypersensitivity pneumonitis (HP) induced by isocyanates in Japan. It is said that HP is one of the rare diseases induced by isocyanate with very low frequency so far in the wo
Although polymorphisms in RIP2 are not likely to be associated with the development of asthma, the genetic variants might contribute to asthma severity in the Japanese population.
Our results indicate that IgE-dependent Zn release from human MCs involves signaling cascades that are distinct from those of degranulation. Thus, Zn may have a unique function as a mediator of allergic inflammation.
Currently, targeted alpha therapy (TAT) is a new therapy involving the administration of a therapeutic drug that combines a substance of α-emitting nuclides that kill cancer cells and a drug that selectively accumulates in cancer cells. It is known to be effective against cancers that are difficult to treat with existing methods, such as cancer cells that are widely spread throughout the whole body, and there are high expectations for its early clinical implementation. The nuclides for TAT, incl
