The University of Tokyo · 공학
카즈마 마와타리 교수의 연구실은 나노미세 채널 내에서의 액체 거동을 다루는 '확장된 나노유체역학(extended-nanofluidics)'을 핵심으로 하며, 피코리터 이하의 초미세액체를 제어하고 분석하는 기술 개발에 주력하고 있습니다. 특히 단일 분자 및 단일 세포 분석을 위한 초고감도 검출 기술, 예를 들어 열렌즈 현미경을 활용한 나노입자 단일 검출과 비기계식 나노밸브(Laplace nanovalve) 기반의 유체 제어 기술이 핵심 연구 방향입니다. 임상 진단과 세포 분석을 위한 마이크로칩 기반 분석 시스템의 통합 및 실용화도 중요한 목표입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Engineering using liquids confined in channels 10-1000 nm in dimension, or "extended-nanofluidics," is the next target of microfluidic science. Liquid properties at this scale were unrevealed until recently because of the lack of fundamental technologies for investigating these ultrasmall spaces. In this article, the fundamental technologies are reviewed, and the emerging science and technology in the extended-nanospace are discussed.
We have developed a thermal lens microscope for liquid-phase and surface microanalyses. By applying the thermal lens microscope to particle detection, we succeeded in detecting a pulsed photothermal signal from single-nanometer-sized particles in liquid and counting them individually. The samples were polystyrene latex particles (190 and 80 nm in diameter) and colloidal Ag particles (10 nm in diameter). To verify that the detected pulsed signals corresponded to the single-particle photothermal e
Cell analysis and clinical diagnosis systems are now becoming the largest field of application for microchip-based analytical systems. Technological advantages include: small volume, fast analysis time, highly integrated analytical functions, easy operation and small size. For these purposes, basic methodologies for general micro-integration and basic technologies, including fluidic control and ultrasensitive detection, are required. In this review, we introduce our approach to the general integ
Analytical technologies of ultrasmall volume liquid, in particular femtoliter to attoliter liquid, is essential for single-cell and single-molecule analysis, which is becoming highly important in biology and medical diagnosis. Nanofluidic chips will be a powerful tool to realize chemical processes for such a small volume sample. However, a technical challenge exists in fluidic control, which is femtoliter to attoliter liquid generation in air and handling for further chemical analysis. Integrati
