東京大学 · Biochemistry, Genetics and Molecular Biology
카토카 교수의 연구실은 주로 생체적합성 고분자 기반 나노의약제 개발을 핵심으로 하며, 특히 고분자 미세구조를 이용한 약물 전달 시스템과 세포 내 정밀 약물 방출 메커니즘을 연구하고 있습니다. 블록 공중합체를 기반으로 한 나노입자 설계, 특히 난류성 및 pH 민감성 구조를 통한 암세포 표적 치료와 인슐린 방출 조절 기술이 주요 연구 분야입니다. 생체 내 상호작용을 고려한 초미세 구조 제어와 분자 인식 기반의 정밀 조절 기술이 핵심 기반 기술입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Polymeric micelles are demonstrating high potential as nanomedicines capable of controlling the distribution and function of loaded bioactive agents in the body, effectively overcoming biological barriers, and various formulations are engaged in intensive preclinical and clinical testing. This Review focuses on polymeric micelles assembled through multimolecular interactions between block copolymers and the loaded drugs, proteins, or nucleic acids as translationable nanomedicines. The aspects in
Molecular recognition based on length was found to occur between oppositely charged pairs of flexible and randomly coiled block copolymers in an aqueous milieu. Matched pairs with the same block lengths of polyanions and polycations exclusively formed even in mixtures with different block lengths. These assemblies of the charged segments with matched chain lengths then formed larger core-shell-type supramolecular assemblies with an extremely narrow size distribution due to the strict phase separ
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotally Synthetic Polymer Gels Responding to External Glucose Concentration: Their Preparation and Application to On−Off Regulation of Insulin ReleaseKazunori Kataoka, Hiroaki Miyazaki, Masayuki Bunya, Teruo Okano, and Yasuhisa SakuraiView Author Information Department of Materials Science Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Department of Materials Science Science University of Tok
A new type of multifunctional polymeric micelle drug carrier for active intracellular drug delivery was prepared and characterized in this study. The micelle is a nano-supramolecular assembly with a spherical core-shell structure, and its surface and core were modified with piloting molecules for cancer cells and pH-sensitive drug binding linkers for controlled drug release, respectively. In order to prepare such micelles, self-assembling amphiphilic block copolymers, folate-poly(ethylene glycol
