The University of Tokyo · 생화학·유전·분자생물학
Kazuo Shin-ya 교수의 연구실은 주로 균류 및 방선균에서 유래하는 천연물 합성 경로, 특히 폴리케타이드 합성효소(PKS)를 중심으로 한 생합성 기작과 유전자 클러스터의 진화를 연구합니다. 특히 텔로머라제 억제제인 텔로메스타틴과 같은 생활용 천연물의 생합성 메커니즘을 밝혀내고, 이를 바탕으로 새로운 약물 후보 물질의 설계 및 재프로그래밍 가능한 대사 경로 개발에 기여하고 있습니다. 해양 기반의 균류 및 방선균에서 새로운 생물활성 물질을 탐색하는 생물다양성 탐사도 핵심 연구 분야입니다.
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ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTelomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatusKazuo Shin-ya, Konstanty Wierzba, Ken-ichi Matsuo, Toshio Ohtani, Yuji Yamada, Kazuo Furihata, Yoichi Hayakawa, and Haruo SetoView Author Information Institute of Molecular and Cellular Biosciences The University of Tokyo Bunkyo-ku, Tokyo 113-0032, Japan Graduate School of Agricultural and Life Sciences The University of Tokyo Bunkyo-ku, Tokyo 113-8657, Japan Cite this: J. Am. C
Polyketides form many clinically valuable compounds. However, manipulation of their biosynthesis remains highly challenging. An understanding of gene cluster evolution provides a rationale for reprogramming of the biosynthetic machinery. Herein, we report characterization of giant modular polyketide synthases (PKSs) responsible for the production of aminopolyol polyketides. Heterologous expression of over 150 kbp polyketide gene clusters successfully afforded their products, whose stereochemistr
Terrestrial actinobacteria have served as a primary source of bioactive compounds; however, a rapid decrease in the discovery of new compounds strongly necessitates new investigational approaches. One approach is the screening of actinobacteria from marine habitats, especially the members of the genus Streptomyces. Presence of this genus in a marine sponge, Haliclona sp., was investigated using culture-dependent and -independent techniques. 16S rRNA gene clone library analysis showed the presenc
