Tohoku University · 의학
켄지 후지모리 교수의 연구실은 주로 항체 기반 진단 및 치료의 약리학적 메커니즘을 수학적 모델링과 임상 데이터를 융합하여 연구합니다. 특히 종양 내 항체 분포의 거시적·미세적 동역학, 방사성 표지 항체의 선별적 배포 및 선량 평가에 중점을 두고 있으며, PMX(혈장 흡착 치료)의 임상적 효과를 분석한 대규모 환자 데이터 연구도 진행하고 있습니다. 이는 정밀의료와 개인화 치료 전략 개발에 기여하고자 하는 핵심 목표를 지닙니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
For successful use of radiolabeled monoclonal antibodies (MAbs) for diagnosis and therapy, it is helpful to understand both global and microscopic aspects of antibody biodistribution. In this study, antibody distribution in a tumor is simulated by splicing together information on global pharmacokinetics: transport across the capillary wall, diffusive penetration through the tumor interstitial space, and antigen-antibody interaction. The geometry simulated corresponds to spherical nodules of dens
In order to understand the pharmacology of monoclonal antibodies and their conjugates, one must consider both global and microscopic aspects of antibody distribution. Here we present an analysis of antibody distribution in tumors based on the following factors: (a) molecular weight and valence of the antibody; (b) global pharmacokinetic profile following i.v. bolus injection; (c) penetration through the vascular wall; (d) diffusive and convective transport through interstitial space in the tumor
Analysis of a large-scale Japanese inpatient database found a significant association between PMX efficacy and baseline SOFA score. This result indicates higher efficacy in patients with medium SOFA scores in the range of 7-12. The result provides a promising hypothesis for selecting appropriate patients for PMX and should be validated in future RCTs.
Accurate dosimetry is essential for the assessment of radioimmunotherapy. Most often studied to date has been the macroscopic dosimetry related to organ and tumor distribution of the radiolabeled antibody, but the question of microscopic dose heterogeneity is also important. To address the latter issue, we have taken an integrated approach to the pharmacology, taking into account whole-body distribution, transcapillary transport, percolation through the tumor interstitial space, antigen-antibody
Analysis of large Japanese databases showed that septic shock patients who received noradrenaline might benefit from PMX treatment.
Although Tc-99m-labeled RBC SPECT is sensitive for detection of intestinal bleeding, it cannot provide a high degree of specific anatomic information. We present a case of intestinal bleeding in which a fused image composed of those from Tc-99m-labeled RBC SPECT and from x-ray CT revealed small intestinal bleeding with specific anatomic information. We believe that the fused image is useful for anatomic localization of gastrointestinal bleeding and helpful for surgical intervention.
