Hokkaido University · 화학
켄지 모네 교수의 연구실은 주로 생물학적 활성 화합물의 생합성과 입체화학적 특성 규명을 중심으로 연구를 진행하고 있습니다. 특히 식물에서 생성되는 희귀한 유기 할로겐화 화합물의 생합성 메커니즘과 당류의 비대칭 구조를 정밀하게 분석하기 위한 진동 circular 디클로이즘(VCD) 기법의 응용에 초점을 맞추고 있습니다. 이는 자연물의 구조-기능 관계 규명과 신약 개발에 기여하는 핵심 연구 분야입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Vibrational circular dichroism (VCD) technique successfully revealed the absolute configuration of the biased helix of perfluoroalkyl chains in solution with the aid of theoretical calculations, which was supported by an X-ray crystallographic study.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of Cruciferous PhytoalexinsKenji Monde, Mitsuo Takasugi, and Toshiyuki OhnishiCite this: J. Am. Chem. Soc. 1994, 116, 15, 6650–6657Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ja00094a021https://doi.org/10.1021/ja00094a021research-articleACS PublicationsRequest reuse permissionsArticle Views363Altmetric-Citations52LEARN ABOUT THESE METRICSAr
Seven chlorine-containing orcinol derivatives (2-8) and orcinol (9) have been isolated from diseased bulbs of the edible lily Lilium maximowiczii, and their structures have been elucidated. Six of the chlorinated orcinol derivatives (2, 4-8) showed antifungal activity. Because organochlorine compounds are rare in terrestrial higher plants, their biosynthetic origin was examined. These compounds were shown to be induced in intact bulb scales by UV irradiation or by inoculation with the pathogenic
The vibrational circular dichroism (VCD) technique was applied to carbohydrates and produced a glycoside characteristic VCD band, which was named the "glycoside band." It confirmed that this vibration was related to anomeric configurations of carbohydrates in the case of the d-series by means of isotope substitution. This band is defined as a negative, sharp, and intense VCD band at around 1145 cm-1, exhibited by d-sugars with an axial alpha-glycosidic linkage in the 4C1 conformation. As applica
