Ki‐Bong Oh
서울대학교 의과대학 · 의학
Ki-Bong Oh 교수의 연구실은 주로 병원성 진균류와 해양 생물에서 유래한 생활물질의 생리활성 메커니즘을 규명하는 데 초점을 맞추고 있습니다. 특히 칸디다 알바이칸스의 형질 전환 메커니즘과 항진균 작용을 보이는 식물 및 해양 생물 유래 화합물의 정제 및 생물학적 평가를 중심으로 연구를 진행하고 있습니다. 이들의 연구는 신약 개발 및 항균제의 새로운 타겟 발견에 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The yeast Candida albicans has a distinguishing feature, dimorphism, which is the ability to switch between two morphological forms: a budding yeast form and a multicellular invasive filamentous form. This ability has been postulated to contribute to the virulence of this organism. Studies on the morphological transition from a filamentous to a budding yeast form in C. albicans have shown that this organism excretes an autoregulatory substance into the culture medium. This substance was extracte
Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp. were investigated using several biological assays. In the evaluation of antimicrobial activity against various strains of bacteria and fungi, compounds of the hamacanthin class exhibited more potent antibacterial activity than those of the topsentin class. Deoxytopsentin (1) and hamacanthin A (5) also exhibited significant antibacterial activity against methicillin-r
The antifungal activity of Portulaca oleracea extracts against hyphal growth of various fungi was evaluated in real time using an automatic single-cell bioassay system. Target organisms were the filamentous fungi Aspergillus and Trichophyton and the yeast Candida. A colony of test fungi was in contact with the assay medium, or assay medium containing plant extract, in sequence. The antifungal activity of each fraction of P. oleracea was evaluated based on the dynamic hyphal growth response curve
