성균관대학교 · 의학
서경철 교수의 연구실은 심혈관 질환의 조기 생체지표 탐색과 대사질환의 예방 및 기전 규명을 핵심 연구 분야로 삼고 있습니다. 특히 단백뇨, CRP, 페리틴, 지방간, 신체 활동 등 다양한 생체마커와 생활습관이 심혈관 질환 및 대사질환에 미치는 영향을 한국인을 중심으로 체계적으로 연구하고 있습니다. 다양한 생체지표와 생활행동의 상호작용을 통해 개인화된 예방 전략을 모색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Low levels of albuminuria, UACR below 30 mg/g, are associated with increased risk of incident hypertension and CVD mortality at follow-up, but are not associated with increased risk of incident diabetes mellitus.
C-reactive protein concentrations are substantially lower in Koreans than reported for whites populations. Nonetheless, C-reactive protein levels are associated with CVD and all-cause mortality in Korean men. Standard cut points for C-reactive protein may under-represent Asians at risk for CVD.
Increased ferritin concentrations are associated with the presence of a marker of early coronary artery atherosclerosis, independently of traditional cardiovascular risk factors including Framingham risk score, transferrin, preexisting vascular disease, diabetes mellitus, metabolic syndrome factors, and low-grade inflammation.
In this large population of individuals of Korean ancestry, results indicate that while overall (BMI) and abdominal (waist circumference) overweight/obesity are associated with features of NAFLD, surrogate estimates of insulin resistance, FPI concentration, and TG/HDL-C ratio predict NAFLD independently of age, BMI, and waist circumference.
We found a positive, graded association between physical activity and the prevalence and the progression of CAC, regardless of baseline CAC scores.
Alcohol intake is associated with increasing BMI and several metabolic abnormalities, including higher fasting glucose. Paradoxically, it is also associated with lower insulin concentrations. The clinical significance of these findings needs further investigation.
This study showed that the predictive value of ABSI for mortality risk was strong for a sample of young Asian participants and that its usefulness was better than BMI or WC.
HbA(1c) increased as cardiovascular risk factors increased and HbA(1c) of 5.45% predicted the presence of MS. HbA(1c) might be a predictive measure of IFG and MS, and also cardiovascular risk factors in the Korean population.
These data suggest that high baseline fasting insulin levels are independent determinants for the future development of MS.
