Hokkaido University · 의학
Kumiko Yoshimatsu 교수의 연구실은 항암제 개발과 암 관련 신호전달 분자 기전을 중심으로 한 분자 약리학 및 생물학적 기전 연구를 수행하고 있습니다. 특히 항암 작용을 보이는 새로운 화합물(E7010)의 세포 독성 메커니즘과 프로스타글랜딘 E 합성효소(mPGES)의 암 발생과의 연관성 등 암 생물학적 기전을 규명하는 데 초점을 맞추고 있으며, 만성 신장질환의 원인 미스터리(CKDu) 및 헌타바이러스 단백질의 다량체화가 면역 반응에 미치는 영향 등 다양한 질병 기전 연구도 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
E7010 (N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonami de), an orally active sulfonamide antitumor agent that is currently in a Phase I clinical trial, showed rather consistent growth-inhibitory activities against a panel of 26 human tumor cell lines (IC50 = 0.06-0.8 microg/ml), in contrast to vincristine (VCR; IC50 = 0.0002-0.04 microg/ml), 5-fluorouracil (IC50 = 0.2-30 microg/ml), Adriamycin (IC50 = 0.002-0.7 microg/ml), mitomycin C (IC50 = 0.007-3 microg/ml), 1-beta-D-ara
An inducible microsomal form of human prostaglandin E synthase (mPGES) was recently identified. This enzyme converts the cyclooxygenase (COX) product, prostaglandin (PG) H2, to PGE2, a prostanoid that has been implicated in carcinogenesis. Increased amounts of PGE2 are detected in many types of cancer, but the underlying mechanism is not fully understood. Hence, we compared amounts of mPGES in 19 paired samples (tumor and adjacent normal tissue) of non-small cell lung cancer (NSCLC). By immunobl
Chronic kidney disease (CKD) is recognized as a major public health problem worldwide and in South Asia including Sri Lanka.1Mishra S. Adhikari S. Sigdel M. Nedkoff L. Briffa T. Chronic kidney disease in South Asia.Lancet Glob Health. 2016; 4: e523Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar Initially reported in the 1990s, the health authorities of the dry zone areas of Sri Lanka have identified a high prevalence of CKD in cases without known risk factors. This new form of
Multimerization of the Hantaan virus nucleocapsid protein (NP) in Hantaan virus-infected Vero E6 cells was observed in a competitive enzyme-linked immunosorbent assay (ELISA). Recombinant and truncated NPs of Hantaan, Seoul, and Dobrava viruses lacking the N-terminal 49 amino acids were also detected as multimers. Although truncated NPs of Hantaan virus lacking the N-terminal 154 amino acids existed as a monomer, those of Seoul and Dobrava formed multimers. The multimerized truncated NP antigens
