고려대학교 · 생화학·유전·분자생물학
김경헌 교수의 연구실은 생물학적 분해 효소와 해양 생물에서 유래한 생체활성 물질을 중심으로 한 친환경 자원 회수 및 기능성 소재 개발을 연구하고 있습니다. 특히 식물 세포벽 분해 단백질인 엑스파신 유사 단백질과 PET 플라스틱의 효율적 분해를 위한 생분해 촉매 기반의 일괄 공정 개발에 주력하고 있으며, 해조류에서 추출한 당류 유도체가 피부 건강에 미치는 기능성 효과에도 초점을 맞추고 있습니다. 이는 순환형 경제와 기능성 화장료 소재 개발을 위한 기초 연구로 이어집니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Expansin is a plant protein family that induces plant cell wall-loosening and cellulose disruption without exerting cellulose-hydrolytic activity. Expansin-like proteins have also been found in other eukaryotes such as nematodes and fungi. While searching for an expansin produced by bacteria, we found that the BsEXLX1 protein from Bacillus subtilis had a structure that was similar to that of a beta-expansin produced by maize. Therefore, we cloned the BsEXLX1 gene and expressed it in Escherichia
Poly(ethylene terephthalate) (PET) has been widely used in various industries due to its unique physical properties. However, PET causes major environmental problems globally due to its low degradability and recycling rate. Since it is nearly impossible to replace PET with other materials, an efficient approach for PET recycling is necessary for a circular economy. Herein, for a paradigm shift toward the approach for resource recovery of PET components, we developed an integrated process for dep
Marine algae are considered to be an abundant sources of bioactive compounds with cosmeceutical potential. Recently, a great deal of interest has focused on the health-promoting effects of marine bioactive compounds. Carbohydrates are the major and abundant constituent of marine algae and have been utilized in cosmetic formulations, as moisturizing and thickening agents for example. In addition, marine carbohydrates have been suggested as promising bioactive biomaterials for their various proper
3,6-Anhydro-l-galactose (AHG), a major monomeric constituent of red macroalgae (<i>Rhodophyta</i>), was recently reported to possess skin whitening activity. Moreover, AHG-containing oligosaccharides, such as agarooligosaccharides (AOSs) and neoagarooligosaccharides (NAOSs), have various physiological activities, including anti-inflammatory, antioxidant, and skin moisturizing effects. In this study, AHG and NAOSs were produced from agarose by enzymatic reactions catalyzed by an endo-type β-agara
