Kyoung‐Tak Kang
연세대학교 의예과 · 의학
Kyoung-Tak Kang 교수의 연구실은 인체 관절, 특히 무릎 관절의 생체역학적 기전과 조직공학적 재생 전략을 융합한 연구를 주도하고 있습니다. 고해상도 영상 기반 3차원 무릎 관절 모델링과 기계조절 이론을 활용해 최적의 뼈 및 연골 재생을 위한 고분자 기반 스캐폴드 설계를 연구하며, 특히 퇴행성 관절염 치료를 위한 카르토제니닌 기반 약물 전달 시스템 개발에도 주력하고 있습니다. 이는 임상적 적용에 적합한 생체모방적 솔루션을 개발하는 데 초점이 맞춰져 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The development of successful scaffolds for bone tissue engineering requires concurrent engineering that combines different research fields. In previous studies, phenomenological computational models predicted the mechanical properties of a scaffold in a simple loading condition using the mechano-regulation theory. Therefore, the aim of this study is to predict the mechanical properties of an optimum scaffold required for cartilage regeneration using three-dimensional knee joint developed from m
This article used probabilistic analysis to evaluate material properties of the in vivo subject-specific tibiofemoral (TF) joint model. Sensitivity analysis, based on a Monte Carlo (MC) method, was performed using a subject-specific finite element (FE) model generated from in vivo computed tomography (CT) and magnetic resonance imaging (MRI) data, subjected to two different loading conditions. Specifically, the effects of inherent uncertainty in ligament stiffness, horn attachment stiffness, and
Anatomic TBR and FBR for grade III PLC injuries could restore better biomechanics in the knee joint compared with nonanatomic reconstruction. However, discrepancy with the normal condition requires further modification of surgical techniques.
A surgeon should be prudent in terms of determining the PTS because an excessive increase in the PTS may lead to the progressive loosening of the TF joint due to a reduction in collateral ligament tension and failure of the post in a PE insert. Thus, we support a more individualized approach of optimal PTS determination given the findings of the study.
(1) Background: Although knee arthroplasty or knee replacement is already an effective clinical treatment, it continues to undergo clinical and biomechanical improvements. For an increasing number of conditions, prosthesis based on an individual patient's anatomy is a promising treatment. The aims of this review were to evaluate the clinical and biomechanical efficacy of patient-specific knee prosthesis, explore its future direction, and summarize any published comparative studies. (2) Methods:
HTO should be performed while considering a medial opening wedge HTO to avoid a type II and type III LHF as a potential complication.
The wear of tibial inserts in total knee arthroplasty (TKA) remains a major limitation of longevity. However, wear tests are expensive and time-consuming. Computational wear prediction using a finite-element (FE) model followed by validation through comparison with experimental data is effective for assessing new prosthetic designs or materials prior to functional testing and surgical implementation. In this study, the kinematics, volumetric wear, and wear depth of tibial inserts made of differe