Kyung‐Min Park
서울대학교 생화학·유전학·분자생물학과 · 생화학·유전·분자생물학
Kyung-Min Park 교수의 연구실은 생체적합성 고분자 소재를 기반으로 한 조직 재생 의료 기술과 약물 전달 시스템 개발에 초점을 맞추고 있습니다. 특히, 효소 유도 고분화를 통해 즉시 경화되는 생분해성 하이드로젤을 설계하여 세포 부착, 생장 및 3차원 생체 모델링에 응용하고 있습니다. 또한 천연 식물성 성분을 활용한 친환경적 비항생제 소재 개발을 통해 식품 안전성과 생체재료의 지속 가능성을 동시에 고려한 연구를 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
An in situ cross-linkable gelatin–poly(ethylene glycol)–tyramine (GPT) hydrogel was developed as a novel injectable material for tissue regenerative medicine. The hydrogel was formed rapidly using horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The gelation times could be controlled from five seconds to over one minute by changing the HRP concentration, and the mechanical properties could be controlled by varying the H2O2 concentration. The storage moduli of the hydrogels ranged from
RGD-conjugated Tetronic–tyramine (RGD–Tet–TA) hydrogels were formed in situ, and cell attachment and spreading on the hydrogels were evaluated for an injectable tissue-regenerative scaffold. The hydrogels were prepared by simple mixing GRGDGGGGGY (RGD–Y) in a tyramine-conjugated Tetronic (Tet–TA) polymer solution in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The physico-chemical properties such as mechanical properties and swelling ratio were evaluated and the con
Chemical antibacterials are widely used to control microbial growth but have raised concerns about health risks. It is necessary to find alternative, non-toxic antibacterial agents for the inhibition of pathogens in foods or food contact surfaces. To develop a non-toxic and "green" food-grade alternative to chemical sanitizers, we formulated a multicomponent antibacterial mixture containing <i>Rosmarinus officinalis</i> L., <i>Camellia sinensis</i> L., citric acid, and ε-polylysine and evaluated
The prevalence and characteristics of low-temperature-tolerant <i>Bacillus cereus</i> (psychrotolerant <i>B. cereus</i>) in green leaf lettuce collected during cold chain were investigated. Among the 101 isolated <i>B. cereus</i> samples, only 18 were capable of growth at 7 °C, and these isolates shared potential health hazard characteristics with mesophilic isolates. Most psychrotolerant <i>B. cereus</i> isolates contained various combinations of <i>nheA, nheB, nheC,</i> <i>hblA, hblA, hblC, hb
Contrary to other solid catalysts, enzymes facilitate more sophisticated chemical reactions because most enzymes specifically interact with substrates and release selective products. Lipases (triacylglycerol hydrolase, EC 3.1.1.3), which can catalyze the cleavage and formation of various acyl compounds, are one of the best examples of enzymes with a unique substrate selectivity. There are already several commercialized lipases that have become important tools for various lipid-related studies, a
Two marine urostylid ciliates, Anteholosticha multicirrata n. sp. and Anteholosticha pulchra (Kahl, 1932) Berger, 2003, were collected from South Korea. These species were identified based on morphology, morphogenesis, and SSU rRNA gene sequence comparison. Anteholosticha multicirrata n. sp. is characterized by the following features: body size 90-125 × 30-45 μm in vivo, shape slender to ellipsoidal in outline, with yellow-greenish cortical granules distributed along and between dorsal kineties
Our results suggest that the VRFAS is strongly sensitive to changes in social competence and thus especially beneficial in short-term clinical trials. In addition, atypical antipsychotics can improve social competence and differentially improve receptive skills and expressive skills in schizophrenia.
