The University of Osaka · 의학
Manabu Fujimoto 교수의 연구실은 자가항체 기반의 류마티스성 질환, 특히 피부염증성 근이영양증(DM)과 관련된 자가항체의 진단적 및 예후적 의미를 중심으로 연구를 진행하고 있습니다. 특히 anti-ARS, anti-155/140(TIF-1) 항체와 같은 특정 자가항체가 암 관련 피부염증성 근이영양증과 연관되어 있음을 규명하며, 자가면역 반응의 기전과 암과의 연관성을 탐구하고 있습니다. B세포 수용체 신호전달 경로에서 CD19와 Lyn 키나제의 상호작용 메커니즘을 규명함으로써 자가항체 생성의 분자 기전을 밝히는 데에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Patients with anti-ARS Abs are relatively homogeneous. However, the distribution and timing of myositis, ILD, and rashes differ among patients with individual anti-ARS Abs. Thus, identification of individual anti-ARS Abs is beneficial to define this rather homogeneous subset and to predict clinical outcomes within the "anti-synthetase syndrome."
This novel MSA is associated with cancer-associated DM and may serve as a diagnostic serological marker for this specific subset.
Anti-155/140 antibodies target TIF-1 family proteins, TIF-1α and TIF-1β, in addition to TIF-1γ. Since TIF-1 proteins have significant roles in oncogenesis, these antibodies may be produced during misdirected antitumor immunity.
'Autoantibody-based classification' of dermatomyositis subsets is now a useful strategy for comprehending the heterogeneous spectrum of dermatomyositis.
Ligation of the B cell Ag receptor (BCR) induces cellular activation by stimulating Src-family protein tyrosine kinases (PTKs) to phosphorylate members of the BCR complex. Subsequently, Src-family PTKs, particularly Lyn, are proposed to phosphorylate and bind CD19, a cell-surface costimulatory molecule that regulates mature B cell activation. Herein, we show that B cells from CD19-deficient mice have diminished Lyn kinase activity and BCR phosphorylation following BCR ligation. Tyrosine phosphor
