Kyoto University · 의학
시오카와 마사히로 교수의 연구실은 자가면역성 췌장염(AIP)과 면역글로불린G4 관련 질환(IgG4-RD)의 발병 기전을 밝히는 데 초점을 맞추고 있습니다. 특히 췌장에 손상을 유도하는 자가항체, 특히 레이닌 511-E8에 대한 항체의 역할과 IgG 항체가 조직에 결합하여 병변을 유도하는 메커니즘을 규명하고 있습니다. 또한 PARP-1 기능 이상과 생식세포 종양의 연관성 등 유전적 요인과 세포 신호전달 경로의 역할을 탐색하며 자가면역질환과 암의 연관성에 대한 통합적 접근을 시도하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Patients with AIP are at high risk of having various cancers. The highest risk for cancer in the first year after AIP diagnosis and absence of AIP relapse after successful treatment of the coexisting cancers suggest that AIP may develop as a paraneoplastic syndrome in some patients.
Autoimmune pancreatitis (AIP), a major manifestation of immunoglobulin G4-related disease (IgG4-RD), is an immune-mediated disorder, but the target autoantigens are still unknown. We previously reported that IgG in patients with AIP induces pancreatic injuries in mice by binding the extracellular matrix (ECM). In the current study, we identified an autoantibody against laminin 511-E8, a truncated laminin 511, one of the ECM proteins, in patients with AIP. Anti-laminin 511-E8 IgG was present in 2
IgG1 and IgG4 from patients with IgG4-RD have pathogenic activities through binding affected tissues in neonatal mice.
Accumulated evidence suggests that poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA repair, cell-death induction, differentiation and tumorigenesis. Parp-1 deficiency also induces trophoblast differentiation from mouse embryonic stem cells during teratocarcinoma-like tumor formation. To understand the relationship of PARP-1 dysfunction and development of germ cell tumors, we conducted a genetic analysis of the PARP-1 gene in human germ cell tumors. Sixteen surgical specimens of germ cel
Our findings highlight the context-dependent roles of HES1 in the adult pancreas and pancreatic cancer.
Ulcerative colitis (UC) is a multifactorial chronic disorder with a high prevalence worldwide. UC affects patients in all age groups; however, pediatric-onset UC is generally more severe than adult-onset UC.1Alatab S. et al.Lancet Gastroenterol Hepatol. 2020; 5: 17-30Abstract Full Text Full Text PDF PubMed Scopus (630) Google Scholar To avoid long-term unfavorable outcomes, such as growth failure, early and proper diagnosis with subsequent treatment is needed for pediatric UC patients. Gastroint
The prognosis of gallbladder cancer (GBC) remains poor, and a better understanding of GBC molecular mechanisms is important. Genome sequencing of human GBC has demonstrated that loss-of-function mutations of E74-like ETS transcription factor 3 (ELF3) are frequently observed, with ELF3 considered to be a tumour suppressor in GBC. To clarify the underlying molecular mechanisms by which ELF3 suppresses GBC development, we performed in vivo analysis using a combination of autochthonous and allograft
Our case is a first report of autoimmune pancreatitis with multiple masses within the pancreas which was pathologically diagnosed by endoscopic ultrasound-guided fine needle aspiration and treated by steroid. The masses disappeared by steroid therapy. Our case is informative to know that autoimmune pancreatitis sometimes exhibits multiple masses within the pancreas and to diagnose it without unnecessary surgery.
