大阪大学 · Medicine
마수루 이시이 교수의 연구실은 면역조절, 뼈 대사, 신경질환 등에서 핵심적인 역할을 하는 세포 수용체와 신호전달 분자의 기능을 규명하는 데 중점을 두고 있습니다. 특히 비타민 D 수용체, 세로토닌 수용체, S1P 수용체, 칼륨 채널 등 다양한 수용체와 이차 신호 분자가 세포 기능과 조직 생리에 미치는 영향을 분자생물학적·전기생리학적 방법으로 연구하고 있습니다. 또한, 골절과 골다공로시스 등 뼈 질환의 발달 기전을 밝혀내기 위한 세포융합 및 세포이동 조절 메커니즘에 대한 기초 연구도 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Immune cells, including dendritic cells, macrophages, and T and B cells, express the vitamin D receptor and 1α-hydroxylase. In vitro studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, has an anti-inflammatory effect. Recent epidemiological evidence has indicated a significant association between vitamin D deficiency and an increased incidence, or aggravation, of infectious diseases and inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus eryt
A multistory transmission tower model to be used in multiconductor analysis by EMTP (Electromagnetic Transients Program) is proposed. The circuit parameters of the model are determined based on the measurement of voltages across the insulator strings on an actual 500 kV transmission tower. The multiconductor lightning surge analysis considered enables one to predict the waveform of each insulator voltage, which is useful in determining the phase and the instant of a back flashover. The new tower
Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular Ca(2+) mobilization and activation of protein kinase C. On the other hand, the even-numbered receptors (M(2) and M(4)) are coupled to G(i/o), and i
Sphingosine-1-phosphate (S1P), a lipid mediator enriched in blood, controls the dynamic migration of osteoclast (OC) precursors (OPs) between the blood and bone, in part via the S1P receptor 1 (S1PR1) which directs positive chemotaxis toward S1P. We show that OPs also express S1PR2, an S1P receptor which mediates negative chemotaxis (or chemorepulsion). OP-positive chemotaxis is prominent in gradients with low maximal concentrations of S1P, whereas such behavior is minimal in fields with high ma
Inwardly rectifying potassium (K+) channels (Kir) in Müller cells, the dominant glial cells in the retina, are supposed to be responsible for the spatial buffering action of K+ ions. The molecular properties and subcellular localization of Müller cell Kir channels in rat and rabbit retinas were examined by using electrophysiological, molecular biological, and immunostaining techniques. Only a single population of Kir channel activity, the properties of which were identical to those of KAB-2/Kir4
These data suggest that function of tetraspanin CD9 and its expression in lipid rafts are crucial for cell fusion during osteoclastogenesis.
The mechanism behind the spatiotemporal control of cancer cell dynamics and its possible association with cell proliferation has not been well established. By exploiting the intravital imaging technique, we found that cancer cell motility and invasive properties were closely associated with the cell cycle. In vivo inoculation of human colon cancer cells bearing fluorescence ubiquitination-based cell cycle indicator (Fucci) demonstrated an unexpected phenomenon: S/G2/M cells were more motile and
