Hokkaido University · 의학
마츠오카 타케케 교수의 연구실은 연골 재생 및 소프트티슈스 sarcoma(Soft Tissue Sarcoma, STS)의 분자 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 C57Bl/6 마우스를 이용한 연골 손상 모델 개발과 함께, 글리코실화가 연골 복구 과정에서 히퍼트로픽 분화를 조절하는 핵심 메커니즘임을 밝혀내는 데 기여하고 있습니다. 또한 인공지능(AI) 기반 진료 가이드라인과의 일치성 평가를 통해 임상적 응용 가능성도 탐색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
To analyze the genetic and biomolecular mechanisms underlying cartilage repair, an optimized mouse model of osteochondral repair is required. Although several models of articular cartilage injury in mice have recently been established, the articular surface in adult C57Bl/6 mice heals poorly. Since C57Bl/6 mice are the most popular strain of genetically manipulated mice, an articular cartilage repair model using C57Bl/6 mice would be helpful for analysis of the mechanisms of cartilage repair. Th
Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important proce
Patients with STS need to be followed-up by frequent clinical assessments if they have a smoking history.
Risk factors for liver metastasis were deep location, trunk development, larger tumor size, high histological grade, and specific histological subtypes.
Our results clearly indicated that patient backgrounds differed, such as younger age and greater tendencies to affect males, develop in an extremity and show high-grade tumor in patients with FS-B. In contrast, no differences were observed in distant metastatic potential or survival.
Our study demonstrates that AI, specifically ChatGPT, can align with clinical guidelines for soft tissue sarcoma treatment. It also underscores the need for continuous refinement and cautious integration of AI in medical decision-making, particularly in the context of treatment for soft tissue sarcoma.
To the best of our knowledge, this represents the first report of correction osteotomy for varus knee deformity due to premature epiphyseal closure that occurred during treatment with isotretinoin.
