Tohoku University · 의학
마사토 타카세 교수의 연구실은 주로 고혈압 및 대사질환의 유전적·생활습관적 위험 요인을 규명하는 데 초점을 맞추고 있습니다. 특히 일본인을 대상으로 한 체계적 생체정보 분석을 통해 체질량지수, 지방 및 무지방량 지수, 혈액 속 당화혈색소(HbA1c) 수치와의 연관성을 규명하고 있으며, 동맥경화성질환의 예방을 위한 생체지표(예: cIMT)와의 상관관계도 연구하고 있습니다. 또한 유전적 위험 점수와 생활습관 점수를 통합하여 고혈압의 조기 진단 및 예방 전략을 모색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We recommend the use of this new set of prediction equations together with suggested cut-off values, for assessment of spirometry in Japanese children and adolescents.
Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.
Fat mass index was positively related to HbA1c levels. The fat-free mass index was also related to HbA1c levels when we excluded participants who had been identified as having have diabetes.
The cIMT was associated with atherosclerosis risk factors including age, sex, BMI, SBP, HbA1c, non-HDL-C, and HDL-C, and adequate control of risks in high-risk individuals might be required to prevent atherosclerotic cardiovascular diseases.
No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, ca
Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 me
Reduced lung function was associated with higher prevalence of hypertension, independent of smoking status. Assessment of the lung function or blood pressure may be required in individuals with reduced lung function or hypertension.
Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.
FMI was not associated with cIMT in most FFMI subgroups. Conversely, FFMI was positively associated with cIMT independently of FMI.
We present a case of acute pancreatitis in a 14-year-old girl which fulfilled the diagnostic criteria of autoimmune pancreatitis (AIP) and responded to corticosteroid therapy. Imaging studies revealed that the main pancreatic duct was narrow in the head of the pancreas but had been dilated in the body at an earlier stage. The pancreatitis recurred twice when the prednisolone dose was reduced to 10 mg or less but responded each time to an increased dose and has been kept under control with low-do
Our findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.
Lower lung function was associated with higher cIMT in the Japanese population independent of age and smoking. Assessment of atherosclerosis or lung function may be required for individuals with lower lung function or atherosclerosis.
Family history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included 9,001 hypertension-free individuals aged ≥20 years from the Tohoku Medical Megabank Community-Based Cohort Study. Participants were scored on lifestyle factors, including body mass index, urinary sodi
KL-6は血清可溶性糖蛋白抗原のひとつで, 成人領域では間質性肺疾患の活動性を示す血清マーカーとして臨床応用されているが, 小児期の血清KL-6についてはほとんど検討されていない。そこで, 小児期における血清KL-6の基準範囲について検討した。対象は小児群として生後1ヶ月以降16歳までの非呼吸器疾患患児101例を, 新生児群として正常正期産児40例を検討した。結果は小児群の血清KL-6値には性差はなく, 一定の年齢傾向もなかった。白血球数やCRP値とも相関はなかったが, LDH値とは弱い正相関を認めた。基準範囲は83.7～249.9U/ml (中央値149.0U/ml) と算出された。新生児群は小児群よりKL-6値が有意に低値 (p<0.05) であり, その基準範囲は50.8～226.3U/ml (中央値107.2U/ml) となった。新生児群ではKL-6値と性, 在胎週数, 分娩方法, 出生体重, 採血時日齢との関連について検討したが有意な関連はなかった。
Polygenic risk scores (PRSs), constructed from numerous common single nucleotide polymorphisms (SNPs), have emerged as useful tools for predicting future atherosclerotic cardiovascular disease (ASCVD). PRSs have shown independent associations with ASCVD outcomes and are increasingly being considered to enhance risk stratification and guide primary prevention strategies. However, most evidence to date has been derived from populations of European ancestry, and their generalizability to other popu
