서울대학교 · Engineering
김민수 교수의 연구실은 생물의학적 산화 손상, 약물 제제 공정의 수치 시뮬레이션, 그리고 탄성파 제어 기술을 중심으로 다학제적 연구를 수행하고 있습니다. 심장 재관류 손상에서 활성산소종이 세포막 나트륨-칼륨 ATPase에 미치는 영향을 규명한 생물의학적 기전 연구와, 약물 제제의 품질 제어를 위한 이산요소법 기반 공정 시뮬레이션 기술 개발이 주요 과제입니다. 또한, 자유 표면 유동의 정확한 수치 해석과 고도로 설계된 메타표면을 통한 탄성파 모드 변환 기술을 통해 신소재 및 신기능 장치의 설계 원리를 제시하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of O2 radicals and an inhibitor of xanthine oxidase. Ischemia and reperfusion reduced Na+-K+-ATPase activity and specific [3H]ouabain binding to the enzyme in ventricular muscle homogenates and also markedly lowered sodium pump activity estimated from ouabain-sensitive 86Rb+ uptake by ventricular muscle
Process simulation using mathematical modeling tools is becoming more common in the pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can enhance process understanding, reduce experimentation cost and improve product quality. A commonly used mechanistic modeling approach for powder is the discrete element method (DEM). Most pharmaceutical materials have powder or granular material. Therefore, DEM might be widely applied in the pharmaceutical industry. This review
It has been long believed that a total mode conversion between longitudinal and shear elastic waves can only be achieved at a certain incidence angle. Here, we show that a total mode conversion can be achieved for a broad range of incidence angles by a specially designed elastic metasurface, namely, transmodal metasurface. From the generalized reflection law, we found that the incident longitudinal wave can be totally converted to a reflected shear wave over a broad range of incidence angles if
Abstract Numerical simulation of fluid flow with moving free surface has been performed. For the free surface flow, a volume of fluid (VOF)‐based algorithm utilizing a fixed grid system has been investigated. In order to reduce numerical smearing at the free surface represented on a fixed grid system, a new free surface‐tracking algorithm based on the donor–acceptor scheme has been proposed. Novel features of the proposed algorithm are characterized by two numerical tools; the orientation vector
