Tohoku University · 생화학·유전·분자생물학
이 교수의 연구실은 약물 설계 및 약리학 분야에서 핵심적인 과제인 약물의 수용성 향상과 약물 타겟팅 전략 개발에 중점을 두고 있습니다. 특히 분자 평면도와 대칭성의 붕괴를 통한 수용성 향상, 광학적 스위칭 기반 약물 속성 제어, 그리고 불가침한 단백질을 타겟으로 하는 단백질 분해 유도 기법(예: PROTACs, SNIPERs)을 연구하고 있습니다. 이는 암 치료제 개발 및 희귀질환 치료에 응용 가능한 혁신적 접근입니다.
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ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTImprovement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and SymmetryMinoru Ishikawa* and Yuichi HashimotoView Author Information Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan*Phone: +81.3.5841.7849. Fax: +81.3.5841.8495. E-mail: [email protected]Cite this: J. Med. Chem. 2011, 54, 6, 1539–1554Publication Date (Web):February
The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations. In addition, methyl-beta-CD inhibited CYP1A2 and CYP2D6 at higher concentrations.
The reduction behavior of dephosphorization slag on the iron bath in the reduction furnace of the slag regeneration process was researched by test converter experiments. Dephosphorization slag and coke as the reduction agent and the heat source were added to the hot metal in the converter and oxygen was blown through the top lance. During the blowing, the reduction of (P2O5), (FeO) and (MnO) in the slag proceeded simultaneously. The amount of phosphorus and manganese oxide in the slag decreased
We previously showed that disruption of intermolecular interactions, e.g., by lowering the molecular planarity and/or introducing bent structures, improves the aqueous solubility of compounds, and based upon that work, we hypothesized that azobenzene trans-to-cis photoswitching could also be utilized to enhance the aqueous solubility of compounds. Here, we demonstrate that UV/visible light irradiation can reversibly switch the aqueous solubilization of an anti-cancer candidate drug, a low-molecu
