Hokkaido University · 면역·미생물학
Mohamed Abdallah Mohamed Moustafa 교수의 연구실은 주로 동물의 복잡한 생태계 상호작용과 병원성 미생물 간의 상호관계를 탐구합니다. 주요 연구 분야로는 토양 및 장내 미생물군집의 환경적 요인에 의한 변화, 특히 고대 동물(예: 아시아 코끼리, 암컷 캠벨)의 미생물군집 변화를 중심으로 하며, 이는 인간 활동이 야생 동물 건강에 미치는 영향을 이해하는 데 기여합니다. 또한, 진드기 및 병원성 미생물의 분자 생물학적 특성과 유전적 다양성 분석을 통해 병원체 확산 메커니즘을 규명하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Human activities interfere with wild animals and lead to the loss of many animal populations. Therefore, efforts have been made to understand how wildlife can rebound from anthropogenic disturbances. An essential mechanism to adapt to environmental and social changes is the fluctuations in the host gut microbiome. Here we give a comprehensive description of anthropogenically induced microbiome alterations in Asian elephants (n = 30). We detected gut microbial changes due to overseas translocatio
Dromedary camels (<i>Camelus dromedarius</i>) are widely distributed in Africa, the Middle East and northern India. In this study, we aimed to detect tick-borne pathogens through investigating prokaryotic and eukaryotic microorganisms in camel blood based on a metagenomic approach and then to characterize potentially pathogenic organisms using traditional molecular techniques. We showed that the bacteria circulating in the blood of camels is dominated by Proteobacteria, Bacteroidetes, Firmicutes
Ticks are the second most important vector capable of transmitting diseases affecting the health of both humans and animals. <i>Amblyomma testudinarium</i> Koch 1844 (Acari: Ixodidae), is a hard tick species having a wide geographic distribution in Asia. In this study, we analyzed the composition of <i>A. testudinarium</i> whole mitogenomes from various geographical regions in Japan and investigated the population structure, demographic patterns, and phylogeographic relationship with other ixodi
Research on vector-associated microbiomes has been expanding due to increasing emergence of vector-borne pathogens and awareness of the importance of symbionts in the vector physiology. However, little is known about microbiomes of argasid (or soft-bodied) ticks due to limited access to specimens. We collected four argasid species (<i>Argas japonicus</i>, <i>Carios vespertilionis</i>, <i>Ornithodoros capensis</i>, and <i>Ornithodoros sawaii</i>) from the nests or burrows of their vertebrate host
We report blood parameters for 18 adult and 12 juvenile, free-ranging, female Nile monitors (Varanus niloticus) in Egypt. We report differences between adult and young monitors and compare parameters to those of other reptile species.
Ticks have a profound impact on public health. Haemaphysalis is one of the most widespread genera in Asia, including Japan. The taxonomy and genetic differentiation of Haemaphysalis spp. is challenging. For instance, previous studies struggled to distinguish Haemaphysalis japonica and Haemaphysalis megaspinosa due to the dearth of nucleotide sequence polymorphisms in widely used barcoding genes. The classification of H. japonica japonica and its related sub-species Haemaphysalis japonica douglas
This study was the first to examine the spread of pathogenic/endosymbiotic bacterium R. africae in the A. variegatum populations using a mitogenomic approach. The results support both vertical and horizontal transmission of R. africae within A. variegatum. These findings also highlight the potential of R. africae to adapt to multiple animal species, which may complicate efforts to control it as a human pathogen.
Piroplasms, which include <i>Babesia</i> spp. and <i>Theileria</i> spp., are protozoan parasites carried by ticks and commonly cause disease in animals and humans. Those caused by <i>Babesia</i> spp. manifest as fever, anemia, and hemoglobinuria, while <i>Theileria</i> spp. can lead to high fever, diarrhea, and lymphadenopathy. Recently, <i>Theileria capreoli</i> and an undescribed <i>Babesia</i> sp. were detected for the first time in sika deer (<i>Cervus nippon yesoensis</i>) from Hokkaido; ho
Single-molecule sequencing of a triploid, parthenogenetic North American Haemaphysalis longicornis tick allowed for the generation of a highly contiguous genome assembly that, when coupled with extensive transcriptome profiling, resulted in a robust gene catalog containing multiple candidates for further study as anti-tick vaccine antigens.