Keio University · 의학
오야 모โต스케 교수의 연구실은 암의 진행 메커니즘과 생체마커를 중심으로 한 암 생물학 및 병리학 연구를 수행하고 있습니다. 특히 혈액에서의 염증 및 응고 마커(D-이량체, CRP), 전사 인자(NF-κB), 아릴 하이드로카본 수용체(AhR)와 같은 분자 기전이 암의 진행과 예후에 미치는 영향을 규명하고 있습니다. 이는 암의 조기 진단 및 개인화된 치료 전략 수립에 기여할 잠재력을 지닌 연구입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Elevated plasma D-dimer levels in patients with colorectal cancer are associated with relatively advanced tumor stage and short postoperative survival after curative resection. It appears that measurement of preoperative D-dimer level would be useful in the preoperative diagnosis of tumor stage and prediction of postoperative survival.
Although an aggressive phenotype of renal cell carcinoma (RCC) is known to frequently be associated with inflammatory paraneoplastic syndrome including serum C-reactive protein (CRP) elevation, the molecular mechanism underlying this clinical phenomenon as well as what yields the malignant phenotype leading to the progression of RCC has yet to be elucidated. Based on the increased level of inflammatory cytokines such as interleukin-6 in advanced cases of RCC, a cytokine-inducible transcription f
Aryl hydrocarbon receptor (AhR) and the activation of the AhR pathway are involved in xenobiotic-induced toxicity and carcinogenesis. Although xenobiotics, such as cigarette smoke, contribute to the development of urothelial carcinoma (UC), the relationship between AhR and UC is unclear. In the present study, we investigated AhR expression in 209 patients with upper urinary tract UC. The nuclear expression of AhR was significantly associated with histological grade, pathological T stage, lymphov
