Keio University · 의학
Munehiro Furuichi 교수의 연구실은 소아 감염성 질환, 특히 장내 미생물군과 병원성 세균에 의한 혈행감염, 뇌막염 등의 병태생리학적 기전을 중심으로 연구를 진행하고 있습니다. 장내 병원성 병원균의 지속적 존재와 내성 문제를 해결하기 위해 공생 미생물 군집의 치료적 활용 가능성을 탐색하고 있으며, 특히 항생제 내성 세균과 치료 난이도가 높은 병원성 세균(예: *Stenotrophomonas maltophilia*, *Enterobacteriaceae*)에 대한 신속한 진단 및 치료 전략 개발에 초점을 맞추고 있습니다. 또한 소아 간이식 후 감염, CMV 재활성화, 항생제 내성 세균의 임상적 영향 등 소아청소년의 감염질환 전반의 위험 요인과 치료 전략을 종합적으로 분석하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, and may perpetuate dysregulated immunity and tissue damage<sup>1,2</sup>. Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment<sup>3,4</sup>, although an emerging body of evidence suggests that manipulation of the commensal microbiota may be a practical alternative therapeutic
ID consultation was associated with a higher rate of appropriate therapy and may decrease mortality because of enterococcal bacteremia in children.
Stenotrophomonas maltophilia should be considered in breakthrough bacteremia in pediatric patients who receive carbapenems within 7 days prior to onset.
Late-onset BSI developed in 9% of recipients after pediatric LT. Gram-negative rods accounted for the majority of late-onset BSI as a consequence of abdominal infection, but the focus was often unclear. Prolonged operative time at LT and biliary stenosis were independent risk factors for developing late-onset BSI.
Nationwide surveillance of pediatric bacterial meningitis in Japan from 2019 to 2021 revealed two uncommon situations not covered by the recommended empiric treatment that were not rare in Japan, namely, extended-spectrum β-lactamase-producing-producing Escherichia coli in neonates and Listeria monocytogenes in children older than 1 month.
Fulminant hepatic failure was found to be a risk factor for CMV infection independent of CMV serostatus.
Congenital syphilis (CS) is a mother-to-child infection caused by the bacterium Treponema pallidum , transmitted through the placenta. In Japan, the number of syphilis cases has recently increased, accompanied by an increase in CS cases. Thus, automated methods for serum antibodies with serial values, without a 2× dilution sequence, have been widely used. Moreover, benzathine penicillin G was introduced in Japan in 2021. In response to the recent surge in CS, the first edition of the clinical pr
A 3-year-old boy with congenital heart disease (CHD) and trisomy 21 was admitted to our hospital for worsening of dyspnea at the end of March 2020. He was diagnosed with pulmonary atresia with ventricular septal defect (VSD) at birth and had undergone a Rastelli procedure at 1 year of age. He had no obvious contact with people who were diagnosed as COVID-19. On admission, he weighed 11.3 kg, which was 1 kg heavier than usual. Vital signs were as follows: temperature, 36.2 °C; blood pressure, 122
The study identified male, age, vaccine combinations (PCV13 and DPT-IPV), and summer as factors associated with post-vaccination fever in Japanese infants using real-world data from a childcare application.
According to a 20-year long-term study, vaccine strains are the most critical factor influencing primary and secondary vaccine failure in post-transplant live-attenuated vaccination.
The clinical characteristics of the 2 groups were similar; however, patients with COVID-19-associated encephalopathy showed worse discharge neurologic outcomes, warranting cautious interpretation. Enhancing public awareness of the severe outcomes and conducting further research is essential for better understanding its pathogenesis and treatment.
