Nam‐Jung Kim
경희대학교 의예과 · 의학
김남중 교수의 연구실은 주로 유기합성화학과 약물화학의 융합 분야에서 활동하며, 특히 복합적인 생활물질과 약물 후보 물질을 효율적으로 합성하는 새로운 반응법 개발에 중점을 두고 있습니다. 페르마르-팔라듐 촉매를 활용한 일괄 반응, 산화적 사이클화, 그리고 금 나노입자 기반 표면 증폭 라만 스펙트로스코피 기술을 응용한 분석 기법 개발 등 다각도의 접근을 통해 합성의 효율성과 정밀도를 극대화하고 있습니다. 특히 페놀 유도체를 기반으로 한 플라바논 및 플라바논 유도체의 고수율 합성은 자연물 합성과 신약 개발에 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
In the recent decades, N-heterocycles are widely used as versatile scaffolds for the development of biologically active compounds and considered as one of the privileged structures. Among the various N-heterocycles, benzodiazines, a series of bicyclic heterocycles in which benzene rings are fused with 6-membered heterocycles containing two nitrogens are especially interesting, due to their structural conciseness and usefulness as synthetic intermediates, and suitable physicochemical properties a
A variety of flavones were expediently synthesized from readily accessible chromanones via a one-pot sequence involving Pd(II)-catalyzed dehydrogenation and oxidative boron-Heck coupling with arylboronic acid pinacol esters. In particular, the use of arylboronic acid pinacol esters was found to significantly improve the yield of the reaction.
Chemical enhancement of surface-enhanced Raman spectroscopy was investigated using a gold nanoparticle (AuNP)-coated polymer substrate, and an enormous b2-mode signal enhancement arose from the evaporation-induced reorientation of 4-aminobenzenethiol molecules adsorbed onto the AuNP surface. The dynamic analysis of time-dependent increases of chemically enhanced Raman signals enables us to measure the charge coupling strengths between molecules and metal at varying surface environments and to di
A total of 47 flavanones were expediently synthesized via one-pot β-arylation of chromanones, a class of simple ketones possessing chemically unactivated β sites, with arylboronic acids via tandem palladium(II) catalysis. This reaction provides a novel route to various flavanones, including natural products such as naringenin trimethyl ether, in yields up to 92%.
The concise and enantioselective synthesis of 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been accomplished in 11 steps from a known alcohol. The key step of the synthesis involves an asymmetric Rh-catalyzed cycloisomerization of ene-ynone, followed by an olefin isomerization.
Divergent and versatile synthetic routes to flavones and flavanones <i>via</i> efficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2'-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives, <i>via</i> discriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.
An elusive chemical contribution to SERS is investigated by estimating the chemical coupling strengths through a dynamic relative peak analysis during solvent evaporation from a diluted chemical sample that is drop-deposited on a soft SERS substrate.
