Nan Hee Kim
고려대학교 의과대학 예방의학과 · 의학
Nan Hee Kim 교수의 연구실은 노화, 대사질환 및 생체리듬과 관련된 만성질환의 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 생체리듬 이상(예: 저녁형 생체리듬)이 당뇨병, 대사증후군, 근육량 감소 등 노화 관련 대사 이상과 연관됨을 밝혀내며 생체리듬의 대사 조절 기능을 입증했습니다. 또한, 체성지표(WWI), 페투인-A(fetuin-A), 멜라토닌 등 생체내 대사 조절 인자들이 대사질환과 노화에 미치는 영향을 분자생물학적 기전과 함께 연구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.
WWI is an anthropometric index positively associated with fat mass and negatively associated with muscle mass in older adults.
In contrast to MHO subjects, elderly individuals with the MONW phenotype exhibited greater all-cause mortality during 10 years of follow-up.
Depression in elderly Koreans is associated with low body mass and sarcopenia, especially in men.
Diabetic nephropathy associated with hyperglycemia is characterized by glomerular hyperfiltration and endothelial dysfunction. Vascular endothelial growth factor (VEGF) is known to be primarily involved in neoangiogenesis and increased endothelial permeability. The purpose of this study was to investigate VEGF expression in response to high glucose in rat cultured mesangial cells and to identify its signal pathway via protein kinase C (PKC). Rat mesangial cells were cultured with different conce
Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be associated with insulin resistance and type 2 diabetes. The aim of this study was to determine whether melatonin improves hepatic insulin resistance and hepatic steatosis in a FETUA-dep
