Keio University · 의학
나오하사 히아기 교수의 연구실은 위장관계 내 endoscopic submucosal dissection(ESD) 기술의 개선과 표준화를 핵심으로 삼고 있습니다. 특히 고위험 병변의 근치적 제거를 위해 내시경적 절제 기술의 안전성과 정확성을 높이기 위한 신규 기구 개발 및 수술 방법의 최적화에 주력하고 있으며, 병변의 종류와 위치에 맞는 맞춤형 ESD 기법 개발도 진행 중입니다. 또한, ESD 후 상피 재생 및 상처 치유 과정에 대한 기전 연구를 통해 장기적인 치료 성과를 뒷받침하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Background: Although the strip biopsy method and aspiration method are popular endoscopic mucosal resection techniques for its convenience and reliability, they have limitations in resectable tumor size and location. Endoscopic submucosal dissection techniques using the diathermic needle knife or the insulated‐tip diathermic knife have been introduced to overcome this disadvantage, but they have high risks for bleeding and perforation. Therefore, we have developed a new endoscopic submucosal dis
Further development of the technique, devices and training systems will promote worldwide standardization of ESD.
Background: Due to the remarkable progress of endoscopic resection techniques, endoscopic submucosal dissection (ESD) has been widely performed for larger mucosal tumors that would result in large artificial ulcers. The healing process of peptic ulcers has been previously studied in detail; however, no precise investigation for artificial ulcers after ESD has been reported. To confirm the validity of the treatment from the aspect of wound healing, we aimed to clarify the healing process of large ga
The authors investigated whether high-dose methotrexate-induced toxicity differed according to the presence of methylenetetrahydrofolate reductase (MTHFR) or reduced folate carrier 1 (RFC1) genetic polymorphism. The authors studied 15 children with acute lymphoblastic leukemia or lymphoblastic lymphoma who were treated using protocols that included high-dose methotrexate (3.0 g/m), for an overall total of 43 courses. Methotrexate-induced toxicities and the plasma methotrexate concentrations were
Duodenal endoscopic submucosal dissection (ESD) is difficult due to insufficient mucosal elevation, because of the coarse submucosal layer [1]. We report on the "water pressure method" for duodenal ESD.
ABSTRACT Scheduled piecemeal resection has been actively conducted for granular type laterally spreading tumor (LST‐G) in Japan, as long as a definite preoperative diagnosis is made. However, en bloc resection is desirable for depressed lesions (e.g. IIc lesion) as well as non‐granular type laterally spreading tumor (LST‐NG) since they have considerable high risk for submucoasl invasion and require precise histopathological evaluation. Endoscopic submucosal dissection (ESD) has been developed fo
