성균관대학교 · 화학
Neeraj Kumar Mishra 교수의 연구실은 르호듐(III) 촉매를 중심으로 한 C–H 기반 선택적 화학적 기능화 기술을 연구하고 있습니다. 주요 연구 방향은 인돌린, 인돌, 아닐린 유도체 등의 질소 함유 헤테로사이클을 대상으로 한 C–H 결합의 고도로 선택적인 기능화를 통해 생활물질 및 약리학적으로 유의미한 구조를 효율적으로 합성하는 데 중점을 두고 있습니다. 특히, 알릴화, 시아노화, 아미노화 등의 반응을 통해 복잡한 생체활성 화합물의 합성을 단순화하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The linear or branched allyl moieties on aromatic rings are well-known as ubiquitous structural motifs found in a range of natural products and medicinally relevant molecules. They also represent an important class of organic intermediates for the transformation of an olefin group into many useful functional groups. Established methods for the installation of allylic groups rely primarily on nucleophilic substitution or transmetalation of aryl metal complexes to allyl electrophiles, Lewis acid-m
The rhodium(III)-catalyzed direct functionalization of aniline C-H bonds with α-diazo compounds is described. These transformations provide a facile construction of ortho-alkylated anilines with diazo malonates or highly substituted indoles with diazo acetoacetates.
Abstract The rhodium‐catalyzed selective cyanation of CH bonds of indolines and indoles with N ‐cyano‐ N ‐phenyl‐ para ‐methylbenzenesulfonamide is described. This protocol offers a facile access to C‐7 cyanated indolines and C‐2 cyanated indoles with high site selectivity and excellent functional group tolerance. magnified image
Abstract The site‐selective C−H amination reaction of 7‐azaindoles with various benzisoxazoles as amination surrogates under cationic rhodium(III) catalysis is described. This transformation efficiently provides a range of ortho ‐aminated N ‐aryl‐7‐azaindoles with excellent site‐selectivity and functional group compatibility. The formed ortho ‐aminated 7‐azaindoles were readily transformed into biologically relevant heterocycles such as azaindoloacridine, azaindoloacridone, and bis‐indole compou
The pyrimidinyl-directed C–H functionalization of indolines with anthranils as amination sources under rhodium(<sc>iii</sc>) catalysis is described to afford a range of C7-aminated indoline derivatives with excellent site-selectivity and functional group compatibility.
The rhodium-catalyzed oxidative alkenylation of N-benzyltriflamides with olefins followed by an intramolecular cyclization via C-H bond activation is described. This method results in the direct and efficient synthesis of highly substituted isoindoline frameworks.
The Rh(III)-catalyzed C-H functionalization and subsequent intramolecular cyclization between azobenzenes and vinylene carbonate is described herein. Depending on the electronic property of azobenzenes, this transformation results in the formation of (2<i>H</i>)-indazoles or dihydrocinnolin-4-ones through the generation of <i>ortho</i>-alkylated azo-intermediates followed by decarboxylation. Surprisingly, vinylene carbonate acts as an acetaldehyde or acetyl surrogate to enable the [4 + 1] or [4
