The University of Tokyo · 신경과학
마츠모토 노부요시 교수의 연구실은 뇌의 고유한 구조인 CA2 및 편측피부질과 같은 해부학적 영역에서의 신경 기능과 시냅스 기반 메커니즘을 중심으로 연구를 진행하고 있습니다. 특히 기억 형성, 사회적 행동 조절, 공간 인식 등 뇌 기능의 핵심 메커니즘을 전기생리학적, 형광염색 기반 분석을 통해 규명하고자 합니다. 또한 통합된 뇌 기능을 이해하기 위해 행동 실험과 생리적 기록을 융합한 다학제적 접근을 펼치고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The CA2 region is unique in the hippocampus; it receives direct synaptic innervations from several hypothalamic nuclei and expresses various receptors of neuromodulators, including adenosine, vasopressin, and oxytocin. Furthermore, the CA2 region may have distinct brain functions, such as the control of instinctive and social behaviors; however, little is known about the dynamics of the subthreshold membrane potentials of CA2 neurons in vivo. We conducted whole-cell current-clamp recordings from
Normal respiratory and circulatory functions are crucial for survival. However, conventional methods of monitoring respiration, some of which use sensors inserted into the nasal cavity, may interfere with naïve respiratory rates. In this study, we conducted a single-point measurement of electrocardiograms (ECGs) from the pectoral muscles of anesthetized and waking mice and found low-frequency oscillations in the ECG baseline. Using the fast Fourier transform of simultaneously recorded respirator
The design of communication robots remains a relatively underdeveloped field. Such robots are often designed on a trial-and-error basis. Also, the shape of a robot heavily depends on the personal experience of a designer. In this paper, we discuss a method of designing long-term communication robots, which we call "minimal design." It is unlike other industrial robot design methods. We have already produced some such communication robots, and here we provide explanations of them. Furthermore, we
The presubiculum, a subarea of the parahippocampal region, plays a critical role in spatial navigation and spatial representation. An outstanding aspect of presubicular spatial codes is head-direction selectivity of the firing of excitatory neurons, called head-direction cells. Head-direction selectivity emerges before eye-opening in rodents and is maintained in adulthood through neurophysiological interactions between excitatory and inhibitory neurons. Although the presubiculum has been physiol
Ramelteon is used to ameliorate sleep disorders that negatively affect memory performance; however, it remains unknown whether ramelteon strengthens neutral memories, which do not involve reward or punishment. To address this, we monitored behavior of mice treated with vehicle/ramelteon while they performed a novel object recognition task and a spontaneous alternation task. Object memory performance in the novel object recognition task was improved only if ramelteon was injected before training,
Excitatory neurons and GABAergic interneurons constitute neural circuits and play important roles in information processing. In certain brain regions, such as the neocortex and the hippocampus, there are fewer interneurons than excitatory neurons. Interneurons have been quantified via immunohistochemistry, for example, for GAD67, an isoform of glutamic acid decarboxylase. Additionally, the expression level of other proteins varies among cell types. For example, NeuN, a commonly used marker prote
