The University of Osaka · 의학
미요시 교수의 연구실은 대장암, 위암, 식도암 등 소화기계 암의 발달 기전과 예후 예측 생물학적 마커를 중심으로 연구를 진행하고 있습니다. 특히 종양 미세환경, 유전자 재프로그래밍, 템플릿 기반 유전자 발현 조절, 그리고 암세포의 간성 전이와 관련된 단백질(예: ANXA9, TRIB3, SCRN1)의 기능을 규명하고자 하며, 이는 암 치료의 정밀화 및 개인 맞춤 치료 전략 개발에 기여하고자 합니다. 특히, 간세포의 전이 메커니즘과 암세포의 미세환경 변화를 유도하는 유전자 조절 메커니즘에 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Although cancer is a disease with genetic and epigenetic origins, the possible effects of reprogramming by defined factors remain to be fully understood. We studied the effects of the induction or inhibition of cancer-related genes and immature status-related genes whose alterations have been reported in gastrointestinal cancer cells. Retroviral-mediated introduction of induced pluripotent stem (iPS) cell genes was necessary for inducing the expression of immature status-related proteins, includ
These data strongly suggest the usefulness of TRIB3 as a marker for predicting the prognosis of CRC patients, showing a basis for the development of effective treatments for CRC.
The genome-wide depletion of 5-methylcytosines (5meCs) caused by passive dilution through DNA synthesis without daughter strand methylation and active enzymatic processes resulting in replacement of 5meCs with unmethylated cytosines is a hallmark of primordial germ cells (PGCs). Although recent studies have shown that in vitro differentiation of pluripotent stem cells (PSCs) to PGC-like cells (PGCLCs) mimics the in vivo differentiation of epiblast cells to PGCs, how DNA methylation status of PGC
In patients with T4 esophageal cancer who receive CRT followed by curatively resection, myelogenic chemotoxicity is a significant prognostic factor.
Annexin A9 (<i>ANXA9</i>) is involved with the interaction with membrane phospholipids in a Ca<sup>2+</sup>-dependent manner. A previous study has shown that <i>ANXA9</i> expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high <i>AN
The present data strongly suggest that SCRN1 expression is a prognostic factor in CRC patients.
The submucosal invasion depth predicts prognosis in early colorectal cancer. Although colorectal cancer with shallow submucosal invasion can be treated via endoscopic resection, colorectal cancer with deep submucosal invasion requires surgical colectomy. However, accurately diagnosing the depth of submucosal invasion via endoscopy is difficult. We developed a tool to diagnose the depth of submucosal invasion in early colorectal cancer using artificial intelligence. We reviewed data from 196 pati
