Nagoya University · 의학
노리코 사토 아사하라 교수의 연구실은 대사질환과 관련된 만성염증, 산화 스트레스, 그리고 대사 장애가 연관된 질환의 분자 기전을 규명하는 데 초점을 맞추고 있습니다. 비만, 제2형 당뇨병, 비알코올성간지방염(NASH) 등 대사증후군과 관련된 질환에서 면역반응, 산화적 손상, 근육 및 간 기능 유지 메커니즘을 연구하며, EPA, 타키시놀린, 다파글리플로진 등의 약물 및 천연물질의 병용치료 효과를 기반으로 한 새로운 치료 전략을 모색하고 있습니다. 특히, 염증 반응 조절, 산화 스트레스 조절, 근육 및 간 기능 유지에 기여하는 신호전달 경로를 중심으로 기초-임상 연계 연구를 수행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
This study is the first to show that EPA increases the monocyte IL-10 expression in parallel with decrease of arterial stiffness, which may contribute to the antiatherogenic effect of EPA in obese dyslipidemic patients.
This study demonstrates that UCCR is significantly associated with renal dysfunction, the severity of MS, arterial stiffness, and weight change in obese patients. The data of this study suggest that U-CysC could serve as a CVD and CKD risk factor in patients with obesity and MS.
Dapagliflozin add-on therapy in patients with type 2 diabetes reduced myostatin levels significantly and maintained SMM, without significant changes in FGF21 levels.
Type 2 diabetes mellitus is associated with an increased risk of dementia, potentially through multifactorial pathologies, including neuroinflammation. Therefore, there is a need to identify novel agents that can suppress neuroinflammation and prevent cognitive impairment in diabetes. In the present study, we demonstrated that a high-glucose (HG) environment elevates the intracellular reactive oxygen species (ROS) levels and triggers inflammatory responses in the mouse microglial cell line BV-2.
The molecular pathogenesis of nonalcoholic steatohepatitis (NASH) includes a complex interaction of metabolic stress and inflammatory stimuli. Considering the therapeutic goals of NASH, it is important to determine whether the treatment can prevent the progression from NASH to hepatocellular carcinoma. Taxifolin, also known as dihydroquercetin, is a natural bioactive flavonoid with antioxidant and anti-inflammatory properties commonly found in various foods and health supplement products. In thi
These results suggest that secretion of the myokine CXCL1 is stimulated by saturated fatty acids and that CXCL1 promotes myogenesis from satellite cells to maintain skeletal muscle homeostasis.
