Oran Kwon
이화여자대학교 식량생물학과 · 의학
오란 쿤 교수의 연구실은 식품 성분이 대사 및 대사성 질환에 미치는 영향을 중심으로 연구를 진행하고 있습니다. 특히 글루코스 및 프럭토스 흡수를 조절하는 GLUT2 수송체에 대한 식물성 폴리플라노이드의 억제 작용, NAFLD(비알코올성 간지방증)에서의 산화 스트레스 조절, 뼈 건강과 관련된 카로티노이드의 영향 등 식이요법이 만성질환 예방에 기여할 수 있는 메커니즘을 규명하고자 합니다. 연구는 주로 임상 시험과 인구기반 코hort 연구를 기반으로 하여 식이요법과 생체지표 간의 인과관계를 탐색합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We tested whether the dominant intestinal sugar transporter GLUT2 was inhibited by intestinal luminal compounds that are inefficiently absorbed and naturally present in foods. Because of their abundance in fruits and vegetables, flavonoids were selected as model compounds. Robust inhibition of glucose and fructose transport by GLUT2 expressed in Xenopus laevis oocytes was produced by the flavonols myricetin, fisetin, the widely consumed flavonoid quercetin, and its glucoside precursor isoquercit
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic hepatic injury in the world. One of the most important therapeutic strategies for this disease is modulating oxidative stress. This study hypothesized that supplementation of pinitol might exert hepatic protective effects, by modulating oxidative stress in subjects with NAFLD. A randomized, double-blind controlled trial was conducted in 90 subjects with ultrasonography-proven NAFLD, who were randomly assigned to the
Age-related bone loss is a major public health problem. This cross-sectional study examined the association between the dietary intake of carotenoids and bone mineral density (BMD). Data from 8022 subjects (3763 males and 4259 females) aged 30-75 years included in the Korean National Health and Nutrition Examination Survey (2008-2011) were analyzed. BMD was measured by dual-energy X-ray absorptiometry. Intake of carotenoids was estimated using 24-h dietary recall. In multiple linear analysis, af
It is important to understand the association between oxidative stress-related parameters and to evaluate their status in advance of chronic disease development. Further development towards disease can then be prevented by dietary antioxidants. The present study was aimed at assessing the relationship between diet quality, blood antioxidants, and oxidative damage to determine whether the association between these markers differs by oxidative stress status. For a cross-sectional analysis, we used
