The University of Tokyo · 의학
Ryo Asaoka 교수의 연구실은 주로 녹내상 환자의 시신경망막병변 진행을 정량적으로 예측하고, 임상적 검사로도 접근 가능한 표준 측정값을 바탕으로 환자의 시력 관련 삶의 질(VRQoL)과 시야결손 진행을 정밀하게 분석하는 데 초점을 맞추고 있습니다. 특히 랜덤 포레스트, 라소 회귀, 비선형 모델 등 다양한 통계 및 기계학습 기반 예측 모델을 활용해 단기 시야검사 시리즈에서도 높은 정확도로 미래 진행을 예측하는 방법을 개발하고 있으며, 이는 임상적 의사결정에 실질적 기여를 하고 있습니다. 또한 단안 시야검사의 오진 평가와 이중시각 시야 평가를 위한 IVF(이중시각 시야) 평가 방법의 유용성에 대해서도 핵심 연구 주제로 삼고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The VRQoL prediction model with the Random Forest method enables clinicians to better understand patients' VRQoL based on standard clinical measurements of VA and VF.
Monocular measures, such as better eye MD, can give the impression that a patient's VF loss is more degraded than it might be under binocular viewing. This effect is more pronounced in patients with advanced VF defects. The IVF offers a rapid assessment of a patient's binocular VF severity without extra testing.
The purpose of the study was to investigate the correlation between Corneal Visualization Scheimpflug Technology (Corvis ST tonometry: CST) parameters and various other ocular parameters, including intraocular pressure (IOP) with Goldmann applanation tonometry. IOP with Goldmann applanation tonometry (IOP-G), central corneal thickness (CCT), axial length (AL), corneal curvature, and CST parameters were measured in 94 eyes of 94 normal subjects. The relationship between ten CST parameters against
Age and the degree of VF damage were related to future progression. Average IOP was not related to the progression rate; however, fluctuation of IOP was associated with faster progression, although this was not the case when average IOP was below 15 mm Hg.
Purpose.: We evaluated the usefulness of various regression models, including least absolute shrinkage and selection operator (Lasso) regression, to predict future visual field (VF) progression in glaucoma patients. Methods.: Series of 10 VFs (Humphrey Field Analyzer 24-2 SITA-standard) from each of 513 eyes in 324 open-angle glaucoma patients, obtained in 4.9 ± 1.3 years (mean ± SD), were investigated. For each patient, the mean of all total deviation values (mTD) in the 10th VF was predicted u
The VBLR more accurately predicts future VF progression in glaucoma patients compared to conventional OLSLR, especially in short VF series.
Approximately 10 VFs, are needed to achieve an accurate prediction of PW VF sensitivity and mean sensitivity. Prediction error of PW VF sensitivity can be significantly minimized using the M-estimator robust regression model compared with conventional OLSLR.
In both POAG and PACG eyes, VF damage was more pronounced in superior hemifield than inferior hemifield; however, this tendency was more obvious in POAG eyes than in PACG eyes.
The bIOP measurement from CST is independent from CCT, but dependent on CH and CRF.
The MP-3 microperimeter appears to be useful to evaluate central visual function in RP eyes, exhibiting test-retest reproducibility that is equal to, or better than, that observed in HFA 10-2 VFs.
It is important to compare the results of Corneal Visualization Scheimpflug Technology instrument (CST) measurements and Reichert Ocular Response Analyzer (ORA) parameters. The purpose of the study was to investigate the association between CST measurements and ORA parameters in ninety-five patients with primary open-angle glaucoma. Measurements of CST, ORA, axial length (AL), average corneal curvature (CC), central corneal thickness (CCT) and intraocular pressure (IOP) with Goldmann applanation
