Sang Wook Son
고려대학교 의과대학 · 의학
Sang Wook Son 교수의 연구실은 주로 피부질환, 특히 아토피 피부염, 건선 등 만성 염증성 피부질환의 분자 기전을 규명하는 데 초점을 맞추고 있습니다. IL-33과 TSLP의 상호작용, HIF-1α와 BMP6 간의 조절 메커니즘, 그리고 면역세포(예: NK세포)의 표면 수용체 변화 등에서 염증 반응의 조절 원리를 탐구하고 있습니다. 또한 나노입자(예: 음성 금속 나노입자)의 피부 침투 메커니즘과 레이저 치료, 헬리코박터 파일로리 제거 치료 등 임상적 응용도 함께 연구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Together our results showed that anionic GNs penetrate skin better than cationic GNs.
A long-pulsed alexandrite laser without cryogen spray cooling is an effective and safe alternative in the treatment of BN.
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which T-helper type 2 (Th2)-type immune responses are dominant. Th2 cytokine, interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) have been suggested to have an important role in AD. IL-33 is highly expressed in AD, but its role in AD has not yet been fully understood. To further identify the role of IL-33 in AD, we investigated the expression of TSLP induced by IL-33 in keratinocytes. This study revealed that IL-33 induced
Hypoxia-inducible factor-1α (HIF-1α) has been reported to be up-regulated in psoriatic epidermis, resulting in increased proliferation and abnormal differentiation of human keratinocytes (KCs). However, the role of HIF-1α in psoriatic epidermis, which is mainly composed of KCs, is poorly understood. Here, we show that morphogenic protein 6 (BMP6) is down-regulated when HIF-1α is upregulated in patients with psoriasis skin lesions. HIF-1α overexpression in primary human KCs promoted proliferation
Journal Article The response of rosacea to eradication of Helicobacter pylori Get access S W Son, S W Son Departments of Dermatology, Search for other works by this author on: Oxford Academic Google Scholar I H Kim, I H Kim Departments of Dermatology, Search for other works by this author on: Oxford Academic Google Scholar C H Oh, C H Oh Departments of Dermatology, Search for other works by this author on: Oxford Academic Google Scholar J G Kim J G Kim Internal Medicine, Korea University College
Our findings demonstrate that changes in the expression of Fas and CD94/NKG2A receptors on NK cells may occur during new-onset psoriasis, and are likely to contribute to the pathogenesis of psoriasis.
The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of this study was to investigate the significance and regulatory mechanism of Egr-1 in the pathogenesis of psoriasis. Through microarray analysis, we found out that psoriasin (S100A7) ex
