Sang‐Jip Nam
이화여자대학교 화학·나노과학과 · 의학
Sang-Jip Nam 교수의 연구실은 주로 해양 균류 및 해양 미생물에서 유래한 생활물질을 대상으로 하며, 특히 항염증, 항암, 항균 작용을 보이는 고유한 구조의 자연물질을 규명하는 데 집중하고 있습니다. 특히, NF-κB 신호 경로 억제, FXR 수용체 조절, 세포 사멸 유도 등 생물학적 표적을 향한 기전 연구도 병행하고 있습니다. 다양한 스펙트럼의 생물학적 활성을 지닌 메로테르페노이드, 스칼라네 기반 테르펜, 그리고 클로로아로마틱 화합물 등 다양한 자연물의 구조 규명과 생리활성 평가를 핵심 과제로 삼고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Fijiolide A, a potent inhibitor of TNF-alpha-induced NFkappaB activation, along with fijiolide B, were isolated from a marine-derived bacterium of the genus Nocardiopsis. The planar structures of fijiolides A (1) and B (2) were elucidated by interpretation of 2D NMR spectroscopic data, while the absolute configurations of these compounds were defined by interpretation of circular dichroism and 2D NMR data combined with application of the advanced Mosher's method. Fijiolides A and B are related t
<i>Salicornia europaea</i> L. is a halophyte that grows in salt marshes and muddy seashores, which is widely used both as traditional medicine and as an edible vegetable. This salt-tolerant plant is a source of diverse secondary metabolites with several therapeutic properties, including antioxidant, antidiabetic, cytotoxic, anti-inflammatory, and anti-obesity effects. Therefore, this review summarizes the chemical structure and biological activities of secondary metabolites isolated from <i>Sali
Meroterpenoids, meroindenon (<b>1</b>) and merochlorins E (<b>2</b>) and F (<b>3</b>), were isolated from a marine-derived bacterium belonging to the genus <i>Streptomyces</i>. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds <b>1</b>-<b>3</b> possess a tetrahydroxynaphthalene core and a C<sub>15</sub>-isoprene unit. Compounds <b>2</b> and <b>3</b> exhibited strong antibacterial activities against <i>B. subtilis</i>, <i>K.
The isolation and structure elucidation of a new meroterpenoid, actinoranone (1), produced by a marine bacterium closely related to the genus Streptomyces is reported. Actinoranone is composed of an unprecedented dihydronaphthalenone polyketide linked to a bicyclic diterpenoid. The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data. Actinoranone (1) is significantly cytotoxic to HCT-116 human colon cancer cells with an LD50
Three new scalarane-based sesterterpenes, 1- 3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC50 values of 2.4 and 24 microM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) s
