The University of Tokyo · 의학
미와카와 츠루오 교수의 연구실은 뇌경색과 뇌혈관 질환의 유전적 기반을 규명하는 데 초점을 맞추고 있습니다. 특히, ICASO(일부형 뇌경색) 환자 중 RNF213 유전자 변이(c.14576G>A)가 유병률과 관련이 있음을 규명하며, 이 변이가 뇌혈관 병변의 발달에 중요한 역할을 한다는 점을 밝혀냈습니다. 또한, 뇌경색 후 신경세포 사멸 메커니즘과 전자현미경 및 이온 모드 스펙트로스코피(Ion Mobility Spectrometry)를 활용한 분자 생물학적 변화 분석을 통해 뇌 손상의 조기 징후를 규명하고 있습니다. 이는 뇌경색의 조기 진단 및 치료 전략 개발에 기여할 임상의학적 의의를 지닙니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
A particular subset of patients with various phenotypes of ICASO has a common genetic variant, RNF213 c.14576G>A, indicating that RNF213 c.14576G>A variant is a high-risk allele for ICASO.
The present study indicates that a particular subset of Japanese patients with non-MMD ICASO has a genetic variant associated with MMD. Therefore, we propose the existence of a new entity of ICASO caused by the c.14576G>A variant in RNF213.
This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS.
Histopathology and IMS can provide comprehensive and complementary information on cell death mechanisms in the hippocampal CA1 after global ischemia. IMS provided novel data on molecular changes in phospholipids immediately after TGI. Increased level of PC (diacyl-16:0/22:6) in the pyramidal cell layer of hippocampal CA1 prior to the histopathological change may represent an early step in delayed neuronal death mechanisms.
Ischemic cardiac complication is one of the major perioperative complications of surgical treatment for cervical carotid stenosis, carotid endarterectomy (CEA), and carotid artery stenting (CAS), and may greatly affect surgical outcome, especially in elderly patients aged ≥ 80 years. We retrospectively analyzed the records of 259 patients (34 patients aged ≥ 80 years) treated by CEA and 61 patients (12 patients aged ≥ 80 years) treated by CAS at Aizu Chuo Hospital from January 2000 to September
