Sehoon Park
서울대학교 내과학교실 · 의학
Sehoon Park 교수의 연구실은 만성 신장질환과 관련된 위험 요인, 특히 수면 장애, 심방세동, 흡연 등 생활습관과 심혈관계 질환의 영향을 중심으로 신기능 저하의 인과관계를 규명하고 있습니다. 특히 신장 기능 저하와 암 발생 위험, CRRT(지속적 혈액 흡착 치료)의 임상적 추세에 대한 전국적 역학 연구도 진행 중이며, 이는 한국의 신장질환 관리 전략 수립에 기여하고 있습니다. 연구는 관찰적 데이터와 유전자 예측 분석을 융합하여 임상적 실천에 기여할 수 있는 정책적 시사점을 도출하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
These findings support an adverse effect of a short sleep duration on kidney function. Clinicians may encourage patients to avoid short-duration sleeping behavior to reduce CKD risk.
Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea.
Our study supports that AF is a causal risk factor for kidney function impairment. However, an effect of kidney function on AF was not identified in this study.
Genetically predicted and observational tobacco smoking status are significantly associated with poor ageing phenotypes. Healthcare providers may continue to reduce tobacco use, which may be helpful in reducing the burden of ageing and frailty.
CRRT is a widely used treatment strategy for severe acute kidney injury in Korea. The prognosis of CRRT patients has improved compared to the past. This epidemiological study of CRRT in Korea revealed notable trends with regard to time period and geographic region.
Cancer risk varied in pre-dialysis CKD compared to controls, and the association between cancer risk and CKD stage varied depending on the cancer type.
Any of central corneal thicknesses obtained by all 4 measurement modalities might be acceptable before refractive surgery. However, in post-FS-LASIK eyes, measurements using Orbscan were thinner than those obtained with other modalities; in contrast, those with Pentacam or Galilei were comparable with ultrasound pachymetry.
The C score in the Oxford classification is a valid predictive parameter for IgAN prognosis. Additional clinical attention is necessary for IgAN patients with identified cellular or fibrocellular crescents.
Reducing or preventing MetS may reduce the burden of CKD on a population-scale. Clinicians should consider the clinical importance of altering MetS status for risk of CKD.
This study supports kidney function impairment as a causative factor for obstructive lung disease.
Physical activity and television watching causally affect kidney function in the general population.
Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. We collected urine samples from 201, 77, 47, 36 and 136 patients with IgAN, patients with membranous nephropathy, patients with minimal change disease, patients with lupus nephritis and healthy controls, respectively. We determined whe
Few studies have examined gene expression changes occurring in the glomeruli of IgA nephropathy (IgAN) using a sensitive transcriptomic profiling method such as RNA sequencing (RNA-Seq). We collected glomeruli from biopsy specimens from patients with IgAN with relatively preserved kidney function (estimated glomerular filtration rate ≥ 60 mL·min<sup>-1</sup>·1.73 m<sup>-2</sup> and urine protein-to-creatinine ratio < 3 g/g) and from normal kidney cortexes by hand microdissection and performed RN
Health care providers in the nephrology field should be aware of the causal linkage between psychologic wellbeing and kidney function.
