Seong‐Hun Kim
경희대학교 치과학교 · 치의학
이 교수의 연구실은 구강 및 두부외과 영역에서의 정밀 임상 기술과 생물의학적 기초 연구를 융합한 연구를 수행하고 있습니다. 주요 연구 방향은 치열 및 뼈 생체역학을 고려한 치료용 미니임플랜트(예: C-implants(R)))의 생체적 적합성 평가, 치과용 3D 캐리어 및 맞춤형 보철물의 CAD/CAM 기반 설계 및 제작, 그리고 뇌신경퇴행성질환과 관련된 단백질 복합체(예: γ-세크레타제)의 구조 기반 기전 규명입니다. 특히, 치과 임상에서의 정밀 영상 분석과 인공지능 기반 자동 랜드마크 추출 기술의 응용도 활발히 연구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
SLA mini-implants showed relatively lower insertion torque value and angular momentum and higher total energy during removal than the machined implants, suggesting osseointegration of the SLA mini-implant after insertion.
Macromolecular complexes containing presenilins (PS1 and PS2), nicastrin, anterior pharynx defective phenotype 1 (APH-1), and PS enhancer 2 (PEN-2) mediate the intramembranous, gamma-secretase cleavage of beta-amyloid precursor protein (APP), Notch, and a variety of type 1 membrane proteins. We previously demonstrated that PEN-2 is critical for promoting endoproteolysis of PS1 and that the proximal two-thirds of transmembrane domain (TMD) 1 of PEN-2 is required for binding with PS1. In this stud
Macromolecular complexes containing presenilins (PS), nicastrin (NCT), APH-1, and PEN-2 mediate the gamma-secretase cleavage of the beta-amyloid precursor protein and Notch. APH-1 and NCT stabilize the PS1 holoprotein, whereas PEN-2 is critical for endoproteolysis of PS1. To define the structural domains of PEN-2 that are necessary for mediating PS1 endoproteolysis and gamma-secretase activity, we coexpressed APH-1, NCT, and PS1 together with a series of PEN-2 mutants, which harbored deletions i
This study was designed to develop and verify a fully automated cephalometry landmark identification system, based on multi-stage convolutional neural networks (CNNs) architecture, using a combination dataset. In this research, we trained and tested multi-stage CNNs with 430 lateral and 430 MIP lateral cephalograms synthesized by cone-beam computed tomography (CBCT) to make a combination dataset. Fifteen landmarks were manually and respectively identified by experienced examiner, at the preproce
