Seung Il Kim
연세대학교 의과대학 · 의학
이 교수의 연구실은 유방암의 정밀의료를 위한 바이오마커 및 치료 전략 개발에 초점을 맞추고 있습니다. 특히 종양 유래 밖세포소포(EV)를 이용한 조기 진단 기술과, 면역세포의 기능적 이질성 분석을 통한 면역요법 반응 예측 모델 개발이 핵심 연구 방향입니다. 또한, 신약 개발과 관련된 분자 기반의 생물학적 메커니즘 규명 및 환경 미생물의 대사 기작 연구도 함께 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
To increase the pCR rate, type-specific approaches according to subtypes, such as an addition of trastuzumab, increasing the number of cycles or a novel regimen, should be considered.
Extracellular vesicles (EV) have been emerging as potential biomarkers for disease monitoring. In particular, tumor-derived EV (TDE) are known to carry oncogenic miRNA, so they can be used for diagnosis of early cancer by analyzing the expression levels of EV-miRNA circulating in the blood. Here, using our novel microfluidic device, we rapidly and selectively isolate cancerous EV expressing breast cancer-derived surface markers CD49f and EpCAM within 2 minutes. Based on seven candidates of miRNA
Despite being a standard treatment option in breast cancer, immune checkpoint inhibitors (ICIs) are only efficacious for a subset of patients. To gain a better understanding of the antitumor immune response in breast cancer, we examined the heterogeneity of CD8<sup>+</sup> T cells in tumors, metastatic lymph nodes (mLNs), and peripheral blood from patients with early breast cancer (<i>n</i> = 131). Among tissue-resident memory CD8<sup>+</sup> T (T<sub>RM</sub>) cells, including virus- and tumor-
To develop a nomogram predicting probability of axillary pathologic complete response (pCR) in patients with cytologically proven axillary node-positive breast cancer who received neoadjuvant chemotherapy (NAC).The current management of axillary intervention in node-positive breast cancer patients who received NAC is axillary lymph node dissection (ALND) regardless of axillary pCR.We reviewed the records of 415 patients with cytologically proven node-positive breast cancer that were treated with
Thermococcus onnurineus NA1, a sulfur-reducing hyperthermophilic archaeon, is capable of H(2)-producing growth, considered to be hydrogenogenic carboxydotrophy. Utilization of formate as a sole energy source has been well studied in T. onnurineus NA1. However, whether formate can be used as its carbon source remains unknown. To obtain a global view of the metabolic characteristics of H(2)-producing growth, a quantitative proteome analysis of T. onnurineus NA1 grown on formate, CO, and starch was
