Seung‐Jun Lee
연세대학교 의과대학 · 의학
이 교수의 연구실은 심혈관계 및 소화기계의 혈관 및 상피 세포의 생리적·병리적 반응을 중심으로, 혈관 안정성, 염증 반응, 조직 재생 메커니즘을 규명하고 있습니다. 특히 심근경색 후 심장 혈관의 변화와 장내 내피세포 기반 신호전달 경로의 기능을 연구하며, 초음파를 활용한 비침습적 약물 전달 기술 개발도 함께 진행하고 있습니다. 이들의 연구는 심혈관 질환과 장기질환의 조기 진단 및 치료 전략 개발에 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its precise role in postischemic cardiovascular remodeling is poorly understood. Here, we show that Angpt2 plays multifaceted roles in the exacerbation of cardiac hypoxia and inflammation after myocardial ischemia. Angpt2 was highly expressed in endothelial cells at the infarct border zone after myocardial infarction (MI) or
Exogenous glucagon-like peptide-2 receptor (GLP-2R) activation elicits proliferative and cytoprotective responses in the gastrointestinal mucosa and ameliorates experimental small and large bowel gut injury. Nevertheless, the essential physiological role(s) of the endogenous GLP-2R remain poorly understood. We studied the importance of the GLP-2R for gut growth, epithelial cell lineage allocation, the response to mucosal injury, and host-bacterial interactions in Glp2r(-/-) and littermate contro
These results indicate the feasibility of using a low-cost, lightweight cymbal array for enhanced transdermal insulin delivery using ultrasound.
Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiable c
Venule-dependent arteriolar vasoconstriction in NOD mice is mediated by thromboxane and/or angiotensin II.
Abstract This study reports on highly efficient nonlinear optical ionic quinolinium crystals with various aromatic anions possessing different spatial volume for controlling the space‐filling characteristics and introducing halogen substituents having simultaneous electron‐withdrawing and electron‐donating effects. The quinolinium crystals with chloro and bromo substituents having simultaneous electron‐withdrawing and electron‐donating effects on anions exhibit perfect molecular ordering for opt
