The University of Tokyo · 생화학·유전·분자생물학
Shigeki Matsunaga 교수의 연구실은 주로 해양 샘베개에서 유래한 생활물질성 펩타이드를 중심으로 연구를 진행하고 있습니다. 특히 항균, 세포독성, 항진균 작용을 보이는 고유한 구조를 가진 비리보좀 펩타이드들 — 예를 들어 theonellamides, aurantosides, discodermin A — 의 분離, 구조 규명 및 생합성 메커니즘을 규명하는 데 초점을 맞추고 있습니다. 연구는 자연물 합성과 생물학적 활성 간의 관계를 탐구하며, 신약 개발 잠재성을 지닌 화합물의 발견에 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnatoxin-a(s), a potent anticholinesterase from Anabaena flos-aquaeShigeki Matsunaga, Richard E. Moore, Walter P. Niemczura, and Wayne W. CarmichaelCite this: J. Am. Chem. Soc. 1989, 111, 20, 8021–8023Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ja00202a057https://doi.org/10.1021/ja00202a057research-articleACS PublicationsRequest reuse permissi
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheonellamide F. A novel antifungal bicyclic peptide from a marine sponge Theonella spShigeki Matsunaga, Nobuhiro Fusetani, Kanehisa Hashimoto, and Markus WalchliCite this: J. Am. Chem. Soc. 1989, 111, 7, 2582–2588Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00189a035https://doi.org/10.1021/ja00189a035research-articleACS PublicationsRequest reuse per
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheonellamides A-E, cytotoxic bicyclic peptides, from a marine sponge Theonella sp.Shigeki Matsunaga and Nobuhiro FusetaniCite this: J. Org. Chem. 1995, 60, 5, 1177–1181Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/jo00110a020https://doi.org/10.1021/jo00110a020research-articleACS PublicationsRequest reuse permissionsArticle Views697Altmetric-Citations10
An antimicrobial peptide, discodermin A, has been isolated from the marine sponge Discodermia kiiensis. The peptide showed antimicrobial activity as well as an inhibition of starfish embryo development. It appeared to be a tetradecapeptide consisting of D-Cys(O3H), L-Asp, L-MeGlu, L-Thr (2 moles), Sar, D-Pro, D-Ala, D- and L-t-Leu, D-Leu, L-Phe, D-Trp, and L-Arg.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAurantosides A and B: cytotoxic tetramic acid glycosides from the marine sponge Theonella spShigeki Matsunaga, Nobuhiro Fusetani, Yuko Kato, and Hiroshi HirotaCite this: J. Am. Chem. Soc. 1991, 113, 25, 9690–9692Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ja00025a054https://doi.org/10.1021/ja00025a054research-articleACS PublicationsRequest reuse
Marine sponges are shown to be abundant sources of bioactive peptides. Structurally they include linear peptides, peptide lactones, cyclic peptides, and depsipeptides, with number of residues ranging from two to 48. Some of them have highly modified structural features with nonproteinogenic amino acid or hydroxy acid residues, while others have those with minimal alterations from the common ribosomal peptides. The structural characteristics, biogenesis, biological activity, and the issue of prod
