Kyoto University · 의학
Shintaro Yagi 교수의 연구실은 간 이식 및 간 재생 기전에 중점을 두고 있으며, 특히 성인 및 소아를 대상으로 한 생체 기증자 간 이식(LDLT)의 장기적 결과와 예후 요인을 체계적으로 분석하고 있습니다. 특히 포털 정맥압, 간유도성장인자(HGF), 혈관내피세포성장인자(VEGF) 등 간 재생에 영향을 미치는 생리적 및 분자적 요소의 역할을 규명하고 있으며, 이는 이식 성과 향상에 기여합니다. 또한, 기증자 연령, 이식 graft의 크기 및 혈류역학적 특성 등 임상적 요소가 이식 후 회복에 미치는 영향을 다각도로 연구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The liver is a unique organ with an abundant regenerative capacity. Therefore, partial hepatectomy (PHx) or partial liver transplantation (PLTx) can be safely performed. Liver regeneration involves a complex network of numerous hepatotropic factors, cytokines, pathways, and transcriptional factors. Compared with liver regeneration after a viral- or drug-induced liver injury, that of post-PHx or -PLTx has several distinct features, such as hemodynamic changes in portal venous flow or pressure, ti
Several reports claim that portal hypertension after living-donor liver transplantation (LDLT) adversely affects graft function, but few have assessed the impact of portal venous pressure (PVP) on graft regeneration. We divided 32 adult LDLT recipients based on mean PVP during the 1st 3 days after LDLT into a group with a PVP > or = 20 mm of Hg (H Group; n = 17), and a group with a PVP < 20 mm of Hg (L Group; n = 15). Outcome in the H Group was poorer than in the L Group (58.8 vs. 92.9% at 1 yea
Liver graft function was better when PVF and graft compliance were higher and PVP was maintained under 20 mmHg.
Donor age is an independent, strong prognostic factor in adult-to-adult LDLT.
Few studies have examined the long-term outcomes and prognostic factors associated with pediatric living living-donor liver transplantation (LDLT) using reduced and hyper-reduced left lateral segment grafts. We conducted a retrospective, single-center assessment of the outcomes of this procedure, as well as clinical factors that influenced graft and patient survival. Between September 2000 and December 2009, 49 patients (median age: 7 months, weight: 5.45 kg) underwent LDLT using reduced (partia
Similar outcomes were observed for small and large graft use regardless of lobe selection. 0.6% in GRWR was reasonable as the minimum requirement of graft volume in LDLT. However, small grafts should be indicated carefully for high-risk cases.
