The University of Tokyo · 의학
Shotaro Aso 교수의 연구실은 심각한 순환기 질환 및 중증 환자의 생명 연장에 초점을 맞춘 임상 연구를 수행하고 있습니다. 특히, 혈관내외배기형 일시성 혈액순환보조장치(VA-ECMO)의 임상적 결과와 그에 따른 생존율 향상 전략, 예를 들어 내심장배기펌프(IABP)와의 조합 효과에 대한 연구가 중심입니다. 또한, 약물 치료(예: 사이클로스포린 A, 덱스메데토미딘)의 효과와 고위험군에서의 생존에 미치는 영향을 대규모 국가 데이터베이스를 기반으로 분석하고 있습니다. 고급 통계적 방법론(예: 이중단계 최소제곱법, 이중단계 잔차포함법)을 활용한 인과추론 연구도 활발히 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The present nationwide study showed high mortality rates in patients who received VA-ECMO, and in particular in patients with cardiogenic shock and in patients with cardiac arrest. Weaning from VA-ECMO did not necessarily result in survival. Further studies are warranted to clarify risk-adjusted mortality of VA-ECMO using more detailed data on patient background.
In a national inpatient database, intraaortic balloon pumping combined with venoarterial extracorporeal membrane oxygenation was associated with improved mortality and successful weaning from venoarterial extracorporeal membrane oxygenation. Randomized controlled studies are required to confirm the mortality-reducing effect of intraaortic balloon pumping combined with venoarterial extracorporeal membrane oxygenation.
Therapeutic/care management, level III.
Cyclosporine A did not reduce in-hospital mortality in patients with AE-IPF. Randomised controlled studies are required to confirm this apparent lack of effect of cyclosporine A in AE-IPF.
In theory, instrumental variable (IV) analysis, like randomized controlled trials, can adjust for measured and unmeasured confounders. IVs need to meet the following three conditions: (i) they are associated with treatment assignment; (ii) they have no direct association with the outcome and are associated with the outcome exclusively through the treatment; and (iii) they are not associated with any of the measured confounders. Studies have presented several types of IV, including preferences of
Background: Dexmedetomidine has a mild sedative effect and may reduce mortality in mechanically ventilated critically ill patients. However, few studies have examined the effects of dexmedetomidine in patients with sepsis who require mechanical ventilation. The aim of this study was to investigate the association between dexmedetomidine and mortality in patients with sepsis requiring mechanical ventilation, using a nationwide inpatient database in Japan. Methods: Using the Diagnosis Procedure Co
In a Japanese inpatient database study analyzing outcomes from patients with acute exacerbation idiopathic pulmonary fibrosis receiving systemic glucocorticoids, the addition of cyclophosphamide was not associated with improved in-hospital mortality and ventilator-free days.
