Keio University · 의학
Shotaro Chubachi 교수의 연구실은 만성 폐질환, 특히 만성 폐쇄성 폐질환(COPD)의 합병증과 관련된 병태생리학적 메커니즘을 규명하는 데 초점을 맞추고 있습니다. 특히 COPD 환자에서 골다골증, 폐기능 저하, 폐암 발생 위험, 폐동맥고혈압 등 다양한 합병증의 유전적·영상학적 예측 요인을 탐색하고 있으며, 최근에는 코로나19 감염이 COPD 환자에게 미치는 영향에 대해서도 연구를 확장하고 있습니다. 이들의 연구는 임상적 관점에서 환자의 삶의 질 향상과 예후 개선을 위한 기초 자료를 제공합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Abstract Background and objective Osteoporosis is an important systemic comorbidity of chronic obstructive pulmonary disease ( COPD ). However, neither its mechanisms nor its risk factors have been fully elucidated. With regard to genetic factors, low‐density lipoprotein receptor‐related protein 5 ( LRP 5 ) A 1330 V is known to be associated with osteoporosis in the general population, but the influence of this polymorphism in COPD is unknown. The aim of this study was to investigate the potenti
The severity of COPD exacerbation seemed to be temporally stable over 2 years, and even mild exacerbations adversely impacted the health-related quality of life of patients with COPD.
The presence of emphysema or interstitial abnormalities or a combination of both were independent predictors of lung cancer development in COPD patients. Furthermore, lung cancer most often developed in non-emphysematous areas or in interstitial abnormalities.
Patients hospitalized with COVID-19 with Omicron infections showed a lower incidence of critical outcomes than those with Delta infections, and COVID-19 vaccination may contribute to preventing respiratory failure.
In this study, we identified the clinical characteristics of COPD patients with PH detected by echocardiography. The presence of PH assessed by echocardiography was related to future COPD exacerbations and closely related to radiographical emphysema.
Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.
