Kyoto University · 신경과학
Shuji Kaneko 교수의 연구실은 신경세포의 산화 스트레스 반응과 이차적으로 유도되는 세포사와 관련된 이온 채널, 특히 TRPM2 및 TRPV4 채널의 기능을 중심으로 신경퇴행성 질환 및 신경염증의 분자 기전을 규명하고 있습니다. 특히 뇌내 미세혈관세포인 마크로글리아의 활성화 메커니즘과 이온 채널 조절이 뇌질환에 미치는 영향을 연구하며, 간질 치료제의 임상적 안정성과 선천성 기형 유발 위험 요인에 대한 분석도 수행하고 있습니다. 이는 신경세포 생존과 신호전달 조절의 분자 기초를 밝히는 데 초점이 맞춰져 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
A brief exposure to hydrogen peroxide (H2O2) induces severe deterioration of primary cultured neurons in vitro. We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR). In cultured cerebral cortical neurons from fetal rat, TRPM2 proteins were detected at cell bodies and neurite extensions. Application of H2O2 to the cultured neurons elicited an increase in intracellular Ca2+ concentration ([Ca2+]i) caused by Ca2+ influx
Significance _ 0 \\\ K\\K\ -\\ + X0 -ao \\\\y }s\A8FNN NN N\ \\N 0 D Figure 1 Conclusions for increasing values of the
Microglia are intrinsic immune cells in the brain. In response to neurodegenerative events, excessively activated microglia change their shapes and release various cytokines leading to the pathogenesis of central nervous system (CNS) disease. Because the intracellular mechanisms of this process are still unclear, we have evaluated the functional roles of transient receptor potential vanilloid 4 (TRPV4) channel expressed in the microglia. Robust microglial activation after an injection of lipopol
Adjunctive perampanel (8 and 12 mg/d) significantly improved seizure control in patients with refractory POS. Safety and tolerability were acceptable at daily doses of perampanel 4-12 mg.
To assess the relative contribution of antiepileptic drugs (AEDS) to occurrence of congenital malformations, we compared two prospective studies. We analyzed data for 14 AEDs for total daily doses (drug score) and eight background factors. From the first study, the drug score and polytherapy--particularly the use of valproate plus carbamazepine--were suspected to be primary factors for increased incidence of congenital malformation. In the other study, the drug score for each case was decreased,
The physical interaction between the presynaptic vesicle release complex and the large cytoplasmic region linking domains II and III of N-type (Ca(v)2.2) calcium channel alpha(1)B subunits is considered to be of fundamental importance for efficient neurotransmission. By PCR analysis of human brain cDNA libraries and IMR32 cell mRNA, we have isolated novel N-type channel variants, termed Ca(v)2.2-Delta1 and Delta2, which lack large parts of the domain II-III linker region, including the synaptic
