고려대학교 · 의학
소현 김 교수의 연구실은 면역조절 단백질인 IL-18BP의 기능과 구조를 규명하며 염증 반응과 T-helper 1 반응 조절 메커니즘을 연구하고 있습니다. 또한, 비알코올성 간염(NASH)에서 자가포식과 인플라마좀 경로의 기능 장애를 해결하기 위한 약물 기반 치료 전략 개발에 주력하고 있습니다. 고분자 합성 분야에서는 스타형 폴리머의 생합성 및 생분해성 고분자(예: PGCL, PLA)를 이용한 조직공학용 유연한 생체소재 개발도 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL-18 and thereby suppresses the production of IFN-gamma, resulting in reduced T-helper type 1 immune responses. In the present study, four human and two mouse isoforms, resulting from mRNA splicing and found in various cDNA libraries, were expressed, purified, and assessed for binding and neutralization of IL-18 biological activities. Human IL-18BP isoform a (IL-18BPa) exhibited the greatest affinity for
Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved agents for treating NASH, drugs that can enhance autophagy and modulate inflammasome pathways may be beneficial. Here, we investigated the novel mechanism of ezetimibe, a widely prescribed drug for hypercholesterolemia, as a therapeutic option for ameliorating NASH. Human liver samples with steatosis and NASH were analyzed. Fo
Abstract L ‐Lactide was polymerized with stannous 2‐ethylhexanoate (stannous octoate) in the presence of pentaerythritol to investigate multifunctional initiation. The prepared oligomers contain starshaped 4‐arm molecules when the mole ratio of [lactide]/[pentaerythritol] is above 32. The molecular weight of oligomers coincides with the [lactide]/[pentaerythritol] ratio, indicating that pentaerythritol in conjugation with stannous octoate is an initiator for the “living” polymerization of L‐lact
Cyclic mechanical strain has been demonstrated to enhance the development and function of engineered smooth muscle (SM) tissues, and it would be necessary for the development of the elastic scaffolds if one wishes to engineer SM tissues under cyclic mechanical loading. This study reports on the development of an elastic scaffold fabricated from a biodegradable polymer. Biodegradable poly(glycolide-co-caprolactone) (PGCL) copolymer was synthesized from glycolide and epsilon-caprolactone in the pr
The Gravity Recovery and Climate Experiment (GRACE) is a dedicated spaceborne mission to map the Earth’s gravity field with unprecedented accuracy. The GRACE mission is planned to launch in 2001, for a lifetime of approximately 5 years. It consists of two satellites, co-orbiting in nearly polar orbit, at approximately 300-500 km altitude, separated by 100-500 km along track. Primary measurements are the range change between the two satellites, which represents the gravity perturbation difference
Abstract The ring‐opening polymerization of L‐lactide with stannous octoate was investigated in the presence of pentaerythritol. By this way it was possible to prepare higher molecular weight star‐shaped poly( L ‐lactide)s compared with the linear ones obtained by stannous octoate only. The weight‐average molecular weights of linear and star poly( L ‐lactide)s were measured by light scattering analysis from hexafluoro‐2‐propanol solution, and the respective Mark‐Houwink equations were derived. T
