Soo Lim
서울대학교 의과대학 · 의학
소림 교수의 연구실은 비만과 대사질환의 핵심 메커니즘을 규명하고자, 체내 지방 분포, 특히 복부 내장지방과 간·근육 등 장기 내 비정상적 지방 축적(ectopic fat)이 대사증후군과 심혈관계 질환에 미치는 영향을 중심으로 연구를 진행하고 있습니다. 특히 생체전도도법(BIA)을 활용한 근육량 측정 정확도 평가 및 비알코올성간지방증(NAFLD)과 인슐린 저항성, 환경오염물질이 미토콘드리아 기능에 미치는 영향 등 다양한 분야에서 기초와 임상의 다학제적 접근을 펼치고 있습니다. 연구는 주로 고령층을 대상으로 한 인구기반 연구와 실험모델을 결합하여 진행됩니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The average of overweight individual can have differential fat depots in target organs or specific compartments of the body. This ectopic fat distribution may be more of a predictive factor for cardiovascular risk than obesity. Abdominal visceral obesity, a representative ectopic fat, is robustly associated with insulin resistance and cardiovascular risk. Fat depots in the liver and muscle tissue cause adverse cardiometabolic risk by affecting glucose and lipid metabolism. Pericardial fat and pe
Our findings are consistent with the hypothesized role of android fat as a pathogenic fat depot in the MS. Measurement of android fat may provide a more complete understanding of metabolic risk associated with variations in fat distribution.
We evaluate the accuracy of whole body muscle mass (WBMM) and appendicular skeletal muscle mass (ASMM) assessed by bioelectrical impedance analysis (BIA) using an InBody770 machine (InBody, Seoul, Korea) referenced to dual-energy X-ray absorptiometry (DXA) in 507 people (mean age 63.7 ± 10.8 years, body mass index (BMI) 25.2 ± 3.5 kg/m2). Mean WBMMs measured by BIA and DXA were 49.3 ± 6.6 kg and 46.8 ± 6.5 kg in men and 36.1 ± 4.7 kg and 34.0 ± 4.8 kg in women, respectively. The respective effec
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by fat accumulation combined with low-grade inflammation in the liver. A large body of clinical and experimental data shows that increased flux of free fatty acids from increased visceral adipose tissue and de novo lipogenesis can lead to NAFLD and insulin resistance. Thus, individuals with obesity, insulin resistance, and dyslipidaemia are at the greatest risk of developing NAFLD. Conversely, NAFLD is a phenotype of c
