Hokkaido University · 환경과학
Sumitaka Kobayashi 교수의 연구실은 임신 중 모체의 환경 노출이 태아 발달과 출생 결과에 미치는 영향을 중심으로 연구를 진행하고 있습니다. 특히 수은, 카페인, 흡연 유발 물질, PFAS 등 환경 오염물질과 대사 관련 유전자 다형성 간의 상호작용이 출생 체중, 두경지름, 신경발달 등에 미치는 영향을 체계적으로 분석하고 있습니다. 연구는 일본의 출생대사 코hort를 기반으로 한 정밀한 생화학적 분석과 유전적 요인의 통합적 접근을 특징으로 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
There was no association between maternal blood mercury levels and small-for-gestational-age and birth weight among 15,444 pregnant women. In a Japanese population, which has a relatively higher blood mercury level than reported in Western population, reduced birth size was not found to be associated with blood mercury levels, with the exception of birth head circumference.
Prenatal caffeine consumption was associated with birth size. However, as the association between prenatal caffeine consumption and birth size was likely confounded by unpredicted potential factors, our confidence in the true causality of the association is moderate.
A plasma cotinine level of ≥3.03 ng/mL, which included both passive and active smokers, was associated with an increased risk of SGA. This finding is of important relevance when educating pregnant women about avoiding prenatal passive and active smoking due to the adverse effects on their infants, even those born at full-term.
Neurodevelopment was significantly delayed up to 4 years-of-age among boys born to women with GDM.
The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and
Large for gestational age and hypertensive disorders of pregnancy were associated with pre-pregnancy BMI and GWG in either normal weight or overweight/obese women, and the relationship was strengthened when GDM was present. Women with GDM and a BMI of ≥25.0 kg/m<sup>2</sup> are at risk of having small for gestational age and large for gestational age infants depending on GWG.
Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (n<sub>child</sub> = 48,731) and
