서울대학교 · Medicine
Sung Hee Baek 교수의 연구실은 단백질 기능 조절을 핵심으로 삼는 post-translational modifications(PTM) 및 관련 신호 전달 경로의 분자 메커니즘을 연구합니다. 특히, 단백질 안정성 조절에 핵심적인 역할을 하는 degron과 PTM 간의 상호작용, LSD1, ULK1, Androgen Receptor, SUMO 등 핵내 전사 조절 단백질들의 기능 조절 메커니즘을 중심으로 연구를 진행하고 있습니다. 이는 암을 포함한 질병의 발달 기전 규명과 새로운 약물 타겟 발굴에 기여하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins, which control a protein's stability. These regions, called degrons, are often controlled by PTMs, which act as signals to expedite protein degradation (PTM-activated degrons) or to forestall degradation and stabilize a protein (PTM-inactivated degrons). We summarize current knowledge of the regulation of protein stability by various PTMs. We aim to display the variety
Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating gene cyclin D2. Here, we report that Pitx2, in response to the Wntbeta-catenin pathway and growth signals, also can regulate c-Myc and cyclin D1. Investigation of molecular mechanisms required for Pitx2-dependent proliferation, in these cases, further supports a nuclear role for beta-catenin in preventing the histone deacetylase 1-dependent
Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including development, differentiation, inflammation, thermogenesis, neuronal and cerebral physiology, and the maintenance of stemness in stem cells. LSD1 also participates in pathological processes, including c
