Sung Ho Park
UNIST 의과대학 · 의학
Sung Ho Park 교수의 연구실은 면역세포, 특히 매크로포지와 T세포의 활성화 메커니즘을 중심으로 만성 염증성 질환의 발달 기전을 규명하고 있습니다. 특히 고지혈증과 관련된 동맥경화증에서 매크로포지의 이질성과 역할, 그리고 알레르기 천식 모델에서 NRF2와 활성산소종(ROS)이 Th2 세포의 다기능성 발현에 미치는 영향을 집중적으로 연구하고 있습니다. 이는 염증 반응 조절의 분자 기전을 밝히고, 만성 염증 질환의 새로운 치료 타겟을 모색하는 데 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Chronic inflammation is a hallmark of atherosclerosis and macrophages play a central role in controlling inflammation at all stages of atherosclerosis. In atherosclerosis, macrophages and monocyte-derived macrophages are continuously exposed to cholesterol, oxidized lipids, cell debris, cytokines, and chemokines. Not only do these stimuli induce a specific macrophage phenotype, but they also interact extensively, leading to macrophage heterogeneity in atherosclerotic plaques. Herein, we review t
The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse outcomes of COVID-19. In this review, we summarize our current understanding of the innate immune response elicited by SARS-CoV-2 infection and the hyperinflammation that contributes to disease severity
Upon encountering allergens, CD4<sup>+</sup> T cells differentiate into IL-4-producing Th2 cells in lymph nodes, which later transform into polyfunctional Th2 cells producing IL-5 and IL-13 in inflamed tissues. However, the precise mechanism underlying their polyfunctionality remains elusive. In this study, we elucidate the pivotal role of NRF2 in polyfunctional Th2 cells in murine models of allergic asthma and in human Th2 cells. We found that an increase in reactive oxygen species (ROS) in imm
