大阪大学 · Medicine
이 교수의 연구실은 사이토카인, 특히 IL-6의 다기능적 기능과 면역 조절 메커니즘을 중심으로 연구를 이어가고 있습니다. 특히 T세포가 B세포를 활성화하는 데 기여하는 신호 분자인 IL-6의 기원과 기능을 밝혀내며 면역반응 조절의 핵심 분자로 규명했습니다. 류마티스성 관절염과 같은 자가면역질환에서 IL-6의 과잉 생성이 병태생리에 미치는 영향을 분석함으로써, 질병의 기전과 치료 전략 개발에 기여하고 있습니다. 이와 더불어 항체 반응 조절 메커니즘과 B세포 활성화 인자에 대한 기초 연구도 지속 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
IL-6 is a pleiotropic cytokine involved in the physiology of virtually every organ system. Recent studies have demonstrated that IL-6 has a very important role in regulating the balance between IL-17-producing Th17 cells and regulatory T cells (Treg). The two T-cell subsets play prominent roles in immune functions: Th17 cell is a key player in the pathogenesis of autoimmune diseases and protection against bacterial infections, while Treg functions to restrain excessive effector T-cell responses.
This essay summarizes my 40 years of research in immunology. As a young physician, I encountered a patient with Waldenström's macroglobulinemia, and this inspired me to study the structure of IgM. I began to ask how antibody responses are regulated. In the late 1960s, the essential role of T cells in antibody production had been reported. In search of molecules mediating T cell helper function, I discovered activities in the culture supernatant of T cells that induced proliferation and different
Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on the basis of their molecular structures. Accumulating evidence has demonstrated an intimate link between cytokines and various diseases such as allergy, autoimmune diseases, and cancer. The pathogenesis
High levels of interleukin 6 (IL 6/B cell stimulatory factor-2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL 6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL 6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL 6. The data indicate that IL 6 i
Antibodies are one of the key elements in the immune system. On the one hand, they play an essential role in protection against viral and bacterial infections; on the other hand, they are involved in certain autoimmune diseases and in immediate-type hypersensivity. B cells are the only euka ryotic cells that can produce antibody molecules. The regulated production of antibody molecules is one of the most complex examples of eukaryotic cell differentiation and one of those most. amenable to scie
In the late 1960s, the essential role played by T cells in antibody production was reported. This led to our hypothesis that certain molecules would have to be released from T cells to effect the stimulation of B cells. This hypothesis was shown to be true. There were certain factors present in the culture supernatant of T cells that induced proliferation and differentiation of B cells. The factor that induced B cells to produce immunoglobulins was initially named B cell stimulatory factor-2. Th
